Evidence map›Paper›PMID 37720395›Full record

ArticleNeuro-oncology practice2023

Epigenetic profiling reveals a strong association between lack of 5-ALA fluorescence and

Richard Drexler, Thomas Sauvigny, Ulrich Schüller, Alicia Eckhardt, Cecile L Maire, Robin Khatri, Fabian Hausmann, Sonja Hänzelmann, Tobias B Huber, Stefan Bonn and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Richard DrexlerDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas SauvignyDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ulrich SchüllerInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-8731-1121
Alicia EckhardtInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Cecile L MaireDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Robin KhatriInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fabian HausmannInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sonja HänzelmannInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias B HuberDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan BonnInstitute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0003-4366-5662
Helena BodeResearch Institute Children's Cancer Center Hamburg, Hamburg, Germany.
Katrin LamszusDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Manfred WestphalDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0003-3483-6335
Lasse DührsenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Franz L RicklefsDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: 5-aminolevulinic acid (5-ALA) fluorescence-guided resection increases the percentage of complete CNS tumor resections and improves the progression-free survival of Methods: Patients with newly diagnosed and recurrent Results: Of 74 included patients, 12 (16.2%) patients had a non-fluorescent glioblastoma, which were compared to 62 glioblastomas with 5-ALA fluorescence. Clinical characteristics were equally distributed between both groups. We did not find significant differences between DNA methylation subclasses and 5-ALA fluorescence ( Conclusions: Our study demonstrates an association between non-fluorescent

Indexed as

5-ALA5-aminolevulinic acidEGFRgliomasubclass

Identifiers

PMID37720395
PMCPMC10502788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.