ArticlePatterns (New York, N.Y.)2023
Leakage and the reproducibility crisis in machine-learning-based science.
Article in Patterns (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
303 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Artificial intelligence for predicting surgical difficulty in laparoscopic cholecystectomy: a systematic review and meta-analysis.Surgical endoscopy · 2026Pooled it
- The Role of Machine Learning in Talent Identification for Team Sports: A Systematic Review.Journal of sports science & medicine · 2026Pooled it
- Prognostic models in populations with heart failure: a systematic review and meta-analysis.Systematic reviews · 2026Pooled it
- Landscape of 2D Deep Learning Segmentation Networks Applied to CT Scan from Lung Cancer Patients: A Systematic Review.Journal of imaging informatics in medicine · 2025Pooled it
- The evaluation crisis in artificial intelligence-driven computational biology: Pitfalls and solutions.Quantitative biology (Beijing, China) · 2026Article
- The AHEPA EEG benchmark: setting the standard for machine learning in dementia diagnosis, a scoping review.Cognitive neurodynamics · 2026Article
- Artificial intelligence-driven discovery of coumarin-based therapeutics: Revolutionizing target identification and validation.Pharmaceutical science advances · 2026Review
- Beyond predictive accuracy: A case for mechanism-informed, uncertainty-aware machine learning in food microbiology.iScience · 2026Review
- Reproducibility in biomedical research.Nature medicine · 2026Review
- Multi-omics integration of proteomics and metabolomics in pediatric health and disease.Communications medicine · 2026Review
- Article
- Large Language Models for Clinical Data Extraction in Workplace Injury Rehabilitation: Protocol for a Retrospective Pilot Study of Accuracy, Fairness, and Methodological Considerations in Workers' Compensation Medical Chart Review.JMIR research protocols · 2026Article
- Evaluation of a Pre-Transplant Serum FTIR Rejection-Risk Score Across Time Horizons and Rejection Phenotype-Defined Endpoints in Kidney Transplantation.Journal of personalized medicine · 2026Article
- Review
- Codon optimality predicts mRNA half-life but does not transfer to lncRNAs.Molecular genetics and genomics : MGG · 2026Article
- Sequential Soybean Phenotypes for Grain Yield Prediction in Reciprocal Two-Season Validation.Plants (Basel, Switzerland) · 2026Article
- Artificial intelligence in toxicology: current advances, challenges and future directions.Archives of toxicology · 2026Review
- Machine learning and multi-omics clustering to map cellular rewiring and immune evasion in ccRCC.Human genomics · 2026Article
- Cell-level random splits leak group-owned answers in single-cell benchmarks.bioRxiv : the preprint server for biology · 2026Article
- Classification of Foot-and-Mouth and Lumpy Skin Disease in Cattle Using Frozen Pretrained Encoders: A Comparison of Convolutional and Transformer Architectures.Veterinary sciences · 2026Article
243 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Machine-learning (ML) methods have gained prominence in the quantitative sciences. However, there are many known methodological pitfalls, including data leakage, in ML-based science. We systematically investigate reproducibility issues in ML-based science. Through a survey of literature in fields that have adopted ML methods, we find 17 fields where leakage has been found, collectively affecting 294 papers and, in some cases, leading to wildly overoptimistic conclusions. Based on our survey, we introduce a detailed taxonomy of eight types of leakage, ranging from textbook errors to open research problems. We propose that researchers test for each type of leakage by filling out model info sheets, which we introduce. Finally, we conduct a reproducibility study of civil war prediction, where complex ML models are believed to vastly outperform traditional statistical models such as logistic regression (LR). When the errors are corrected, complex ML models do not perform substantively better than decades-old LR models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.