ReviewFrontiers in bioengineering and biotechnology2023
Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels.
Review in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Engineering Hydrogels for Intrauterine Adhesion Therapy and Endometrial Regeneration.Gels (Basel, Switzerland) · 2026Review
- A thiol-rich immunomodulatory injectable hydrogel suppresses endometrial fibrosis to restore fertilization.Science advances · 2026Article
- Hydrogel-Based Systems in Intrauterine Adhesions: Bridging the Gap from Bench to Bedside.Advanced healthcare materials · 2026Review
- Harnessing Artificial Intelligence for Regeneration of Endometrium in Asherman's Syndrome.Tissue engineering and regenerative medicine · 2026Review
- A bioadhesive antioxidant dual-crosslinked hydrogel mitigates endothelial pyroptosis to enhance ischemic flap survival.Journal of nanobiotechnology · 2026Article
- [Current status of intrauterine adhesion treatment and research progress in stem cell therapy].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Evaluation of endometrial perfusion by arrival time parametric imaging using contrast-enhanced ultrasonography in patients with intrauterine adhesions.Quantitative imaging in medicine and surgery · 2026Article
- Co-delivery of endometrial mesenchymal stem cells and macrophages by an electrospun patch promotes angiogenesis during endometrial injury repair via VEGF related signalling.Stem cell research & therapy · 2026Article
- Hydrogels strategies for organ adhesions: from mechanism to application.Journal of nanobiotechnology · 2026Review
- Dynamic perioperative inflammatory biomarkers predict intrauterine adhesion formation following hysteroscopic myomectomy: a prospective cohort study.Frontiers in medicine · 2026Article
- Integrative bioengineering strategies for endometrial regeneration: From biomaterials and stem cells to organoids and organ-on-a-chip technologies.Theranostics · 2026Review
- Stem cell therapy targets THBS1 to reverse endometrial fibrosis.Frontiers in cell and developmental biology · 2026Article
- Urine-Derived CD105-Positive Exosome Promotes Macrophage M1 Polarization Through the TGF-β1/Smad3 Signaling Axis To Exacerbate Lupus Nephritis.Inflammation · 2025Article
- Nanotechnology strategies for endometrium health: Are we on the right track?Bioactive materials · 2025Review
- Functionalized bacterial cellulose membranes with controlled biodegradation and β-estradiol delivery properties for potential intrauterine adhesion prevention.Journal of materials science. Materials in medicine · 2025Article
- Alkyl side-chain engineering enables significant suppression of conformational relaxation for improved near infrared-II imaging-guided uterine recanalization surgery and cancer phototheranostics.Materials today. Bio · 2025Article
- Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review.Gels (Basel, Switzerland) · 2025Review
- Unveiling the Pathological Landscape of Intrauterine Adhesion: Mechanistic Insights and Exosome-Biomaterial Therapeutic Innovations.International journal of nanomedicine · 2025Review
- Dental pulp stem cell‑derived extracellular vesicles loaded with hydrogels promote osteogenesis in rats with alveolar bone defects.Molecular medicine reports · 2025Article
- The Application of Hydrogels in the Treatment of Intrauterine Adhesions.Current pharmaceutical design · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Intrauterine adhesion (IUA), also referred to as Asherman Syndrome (AS), results from uterine trauma in both pregnant and nonpregnant women. The IUA damages the endometrial bottom layer, causing partial or complete occlusion of the uterine cavity. This leads to irregular menstruation, infertility, or repeated abortions. Transcervical adhesion electroreception (TCRA) is frequently used to treat IUA, which greatly lowers the prevalence of adhesions and increases pregnancy rates. Although surgery aims to disentangle the adhesive tissue, it can exacerbate the development of IUA when the degree of adhesion is severer. Therefore, it is critical to develop innovative therapeutic approaches for the prevention of IUA. Endometrial fibrosis is the essence of IUA, and studies have found that the use of different types of mesenchymal stem cells (MSCs) can reduce the risk of endometrial fibrosis and increase the possibility of pregnancy. Recent research has suggested that exosomes derived from MSCs can overcome the limitations of MSCs, such as immunogenicity and tumorigenicity risks, thereby providing new directions for IUA treatment. Moreover, the hydrogel drug delivery system can significantly ameliorate the recurrence rate of adhesions and the intrauterine pregnancy rate of patients, and its potential mechanism in the treatment of IUA has also been studied. It has been shown that the combination of two or more therapeutic schemes has broader application prospects; therefore, this article reviews the pathophysiology of IUA and current treatment strategies, focusing on exosomes combined with hydrogels in the treatment of IUA. Although the use of exosomes and hydrogels has certain challenges in treating IUA, they still provide new promising directions in this field.
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