Evidence map›Paper›PMID 37720196›Full record

ArticleThe Journal of clinical and aesthetic dermatology2023

The Effects of Oral Isotretinoin on Atrophic Acne Scars Measured by Shear-wave Elastography: An Observational, Single-center Study.

Cemre Busra Turk, Melis Baykara Ulusan, Yusuf Mert Döş, Vildan Manav Baş, Ebru Sarikaya Tellal, Ayse Esra Koku Aksu

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In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cemre Busra TurkDr. Turk is with the Wellman Center for Photomedicine at Massachusetts General Hospital in Boston, Massachusetts.
Melis Baykara UlusanDr. Baykara Ulusan is with the University of Health Sciences Istanbul Training and Research Hospital's Radiology Clinic in Istanbul, Turkey.
Yusuf Mert DöşDrs. Döş, Manav Baş, Sarıkaya Tellal, and Koku Aksu are with the University of Health Sciences Istanbul Training and Research Hospital's Dermatology Clinic in Istanbul, Turkey.
Vildan Manav BaşDrs. Döş, Manav Baş, Sarıkaya Tellal, and Koku Aksu are with the University of Health Sciences Istanbul Training and Research Hospital's Dermatology Clinic in Istanbul, Turkey.
Ebru Sarikaya TellalDrs. Döş, Manav Baş, Sarıkaya Tellal, and Koku Aksu are with the University of Health Sciences Istanbul Training and Research Hospital's Dermatology Clinic in Istanbul, Turkey.
Ayse Esra Koku AksuDrs. Döş, Manav Baş, Sarıkaya Tellal, and Koku Aksu are with the University of Health Sciences Istanbul Training and Research Hospital's Dermatology Clinic in Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although the effects of oral isotretinoin (OI) on acne vulgaris and preventing further acne scars have been well-documented, the specific impact of OI alone on pre-existing atrophic acne scars (AAS) remains unclear. No clinical study has objectively evaluated the effect of OI on AAS yet. Objective: We sought to investigate the OI effect on AAS quantitatively and reliably by shear-wave elastography (SWE). Methods: This work is a single-center, prospective and observational study. Thirty patients with moderate and severe acne vulgaris accompanied by AAS were included. We started the OI with a standard dose regime. On Days 0 and 90 of treatment, patients' global acne grading system (GAGS) and the Goodman and Baron's Qualitative Global Scar Rating System (GSRS) were evaluated. The dermal thickness, subcutaneous tissue thickness, scar size, and scar and subcutaneous tissue's elastic modules were measured on both cheeks of each patient by SWE. Results: The improvement in GSRS stages and GAGS scores in 90 days were statistically significant (respectively; Conclusion: Besides its well-known effect on acne vulgaris, OI also could be an effective treatment option for reducing scar size and severity while improving skin elasticity. SWE may help follow skin and scar properties.

Indexed as

atrophic acne scarsdermal thicknessnon-invasive imagingoral isotretinoinscar therapyShear-wave elastographyskin elasticity

Identifiers

PMID37720196
PMCPMC10503936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.