Evidence map›Paper›PMID 37719942›Full record

ArticleResuscitation plus2023

A recommended preclinical extracorporeal cardiopulmonary resuscitation model for neurological outcomes: A scoping review.

Jin Kook Kang, Andrew Kalra, Syed Ameen Ahmad, Arjun Kumar Menta, Hannah J Rando, Ifeanyi Chinedozi, Zachary Darby, Marcus Spann, Steven P Keller, Glenn J R Whitman and 1 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jin Kook KangDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Andrew KalraDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Syed Ameen AhmadDivision of Neurosciences Critical Care, Department of Neurology, Neurosurgery, Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, USA.
Arjun Kumar MentaDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Hannah J RandoDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Ifeanyi ChinedoziDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Zachary DarbyDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Marcus SpannInformationist Services, Johns Hopkins School of Medicine, Baltimore, USA.
Steven P KellerDivision of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, USA.
Glenn J R WhitmanDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.
Sung-Min ChoDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, USA.

Funding

CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) studyK23HL157610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Sung-Min Cho · 2022 to 2026
$797k
NHLBI NIH HHS K23 HL157610NHLBI NIH HHS L30 HL165486
6 · The paper itself

Abstract

Background: Despite the high prevalence of neurological complications and mortality associated with extracorporeal cardiopulmonary resuscitation (ECPR), neurologically-focused animal models are scarce. Our objective is to review current ECPR models investigating neurological outcomes and identify key elements for a recommended model. Methods: We searched PubMed and four other engines for animal ECPR studies examining neurological outcomes. Inclusion criteria were: animals experiencing cardiac arrest, ECPR/ECMO interventions, comparisons of short versus long cardiac arrest times, and neurological outcomes. Results: Among 20 identified ECPR animal studies ( Conclusions: The substantial heterogeneity in ECPR preclinical model protocols leads to limited reproducibility and multiple challenges. The recommended model includes large animals with both sexes, standardized pre-operative protocols, a cardiac arrest time between 10-15 minutes, use of multimodal methods to evaluate neurological outcomes, and the ability to survive animals after conducting experiments.

Indexed as

Animal modelsCardiac arrestECMOECPRNeurological outcomePreclinical

Identifiers

PMID37719942
PMCPMC10500026

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.