Evidence map›Paper›PMID 37719929›Full record

ArticleRegenerative biomaterials2023

MicroRNA-21a-5p-modified macrophage exosomes as natural nanocarriers promote bone regeneration by targeting GATA2.

Xin Luo, Chunxiu Meng, Yujue Zhang, Qicui Du, Caiyao Hou, Huifen Qiang, Kun Liu, Zhaoyong Lv, Jun Li, Fengzhen Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin LuoBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Chunxiu MengBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Yujue ZhangBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Qicui DuBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Caiyao HouDepartment of Materials Science and Engineering, Liaocheng University, Liaocheng 252000, China.
Huifen QiangDepartment of Materials Science and Engineering, Liaocheng University, Liaocheng 252000, China.
Kun LiuBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Zhaoyong LvBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Jun LiBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.
Fengzhen LiuBiomaterials Laboratory, Liaocheng People's Hospital, Liaocheng Hospital affiliated to Shandong First Medical University, Liaocheng 252000, China.ORCID https://orcid.org/0000-0002-1192-8002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone immune responses based on macrophages are critical in the osteogenesis of bone abnormalities. In general, M2 macrophage facilitate the promotion of osteogenesis, as well, M1 macrophage play an important role in early bone healing, as confirmed by previous studies. However, it is not clear how M1 macrophage are involved in the bone immune response. MiR-21a-5p is a highly expressed microRNA in M1 macrophage in contrast to M2. Therefore, the current work sought to ascertain the influence of M1 macrophage on bone healing via exosomal miR-21a-5p and the probable mechanism. We discovered that injecting M1 macrophage exosomes overexpressing miR-21a-5p into bone defect locations enhanced bone regeneration

Indexed as

bone regenerationexosomesGATA2macrophagesmiR-21a-5p

Identifiers

PMID37719929
PMCPMC10504470

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.