Evidence map›Paper›PMID 37719680›Full record

ArticleBiomedical reports2023

Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p.

Ying Dong, Ting Zhang, Shengwen Shao, Xining Li, Peiyu Jiang, Yue Guo, Donghua Gu

Abstract read
In one paragraph

Article in Biomedical reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying DongSchools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
Ting ZhangSchools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
Shengwen ShaoSchools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
Xining LiSchools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
Peiyu JiangSchools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
Yue GuoSchools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
Donghua GuDepartment of Pathology, Suzhou Science and Technology Town Hospital, Suzhou, Jiangsu 215153, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) has become a threat to women's health. In addition, patients with triple-negative BC (TNBC) have the worst prognosis among all patients with BC. Furthermore, long non-coding RNA ABHD11-AS1 is aberrantly highly expressed in TNBC, suggesting that RNA ABHD11-AS1 may serve as an important role in the progression of TNBC. However, the detailed function of ABHD11-AS1 in TNBC remains largely unknown. The levels of ABHD11-AS1 in MDA-MB-231 cells were assessed by reverse transcription-quantitative PCR. To investigate the effect of ABHD11-AS1 on the progression of TNBC, a xenograft animal model was established. Knockdown of ABHD11-AS1 inhibited the epithelial-mesenchymal transition and migration of TNBC cells. In addition, ABHD11-AS1 promoted the viability and migration of TNBC cells by upregulating microRNA (miR)-199a-5p. Furthermore, knockdown of ABHD11-AS1 suppressed TNBC tumor growth

Indexed as

epithelial-mesenchymal transitionlong non-coding RNA ABHD11-AS1microRNA-199a-5pmigrationtriple-negative breast cancer

Identifiers

PMID37719680
PMCPMC10502577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.