Evidence map›Paper›PMID 37719589›Full record

ArticleCureus2023

Overlapping Autoimmune Diseases: A Case Report and Review of Eosinophilic Granulomatosis With Polyangiitis and Mixed Connective Tissue Disease.

Muaz Shafique Ur Rehman, Muhammad Subhan, Shaina Gulraiz, Ruqiya Bibi, Muhammad Waqas, Anzal Ishfaq, Saad Siddiq Muhammad, Abubakar Gapizov, Faris Fayyaz

Abstract readCase Reports
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muaz Shafique Ur RehmanInternal Medicine, Jinnah Hospital, Lahore, PAK.
Muhammad SubhanInternal Medicine, Jinnah Hospital, Allama Iqbal Medical College, Lahore, PAK.
Shaina GulraizEmergency Medicine, Allama Iqbal Medical College, Lahore, PAK.
Ruqiya BibiMedicine and Surgery, Jinnah Hospital, Lahore, PAK.
Muhammad WaqasInternal Medicine, Jinnah Sindh Medical University, Karachi, PAK.
Anzal IshfaqInternal Medicine, Mayo Hospital, Lahore, PAK.
Saad Siddiq MuhammadInternal Medicine, Inner Mongolia University for Nationalities, Tongliao, CHN.
Abubakar GapizovGeneral Surgery, American University of Antigua, Osbourn, ATG.
Faris FayyazSurgery, Dow University of Health Sciences, Karachi, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a rare case of concurrent eosinophilic granulomatosis with polyangiitis and mixed connective tissue disease in a 27-year-old man who presented with pulmonary, renal, cardiac, and skin manifestations. We confirmed the diagnosis based on clinical, histopathological, and serological criteria. We treated the patient with corticosteroids, methotrexate, cyclophosphamide, and hydroxychloroquine, achieving early remission. The coexistence of both conditions in the same patient is extremely rare and has only been reported in a few cases worldwide. We also review the literature on these two rare autoimmune diseases' coexistence, pathogenesis, diagnosis, and management. Our case emphasizes recognizing overlapping autoimmune conditions in patients with complex clinical features and employing a comprehensive diagnostic approach and tailored treatment strategies. Further research is needed to understand these patients' epidemiology, prognosis, and optimal therapy. Early diagnosis and aggressive immunosuppression are crucial for achieving remission and preventing organ damage. We also identified the knowledge gaps and research needs in this field.

Indexed as

antineutrophil cytoplasmic antibody (anca) associated vasculitis (aav)churg-strauss syndromedermatopathologyeosinophilic granulomatosis with polyangiitis (egpa)granulomatosis with polyangiitis (gpa)panca/mpo (myeloperoxidase)-positive microscopic polyangiitis (mpa)polymyositissle pathogenesissystemic lupus erythematosusvasculitis

Identifiers

PMID37719589
PMCPMC10503782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.