ReviewFrontiers in physiology2023
Effects of the neonatal intensive care environment on circadian health and development of preterm infants.
Review in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cycled light in the intensive care unit for preterm and low birth weight infants.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of combined versus single circadian interventions in neonatal and pediatric intensive care units: a systematic review with meta-analysis.Frontiers in neurologyPooled it
- Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit.Npj biological timing and sleep · 2026Article
- Neurodevelopmental care across pediatric critical care settings: toward brain-focused critical care.European journal of pediatrics · 2026Review
- Diurnal rhythms in melatonin and cortisol in very preterm human milk.Frontiers in nutrition · 2026Article
- Developmental care for preterm infants: a scoping review of interventions, outcomes, and implementation contexts.Frontiers in pediatrics · 2026Review
- Perturbation of the circadian clock in chronic diseases involving organ fibrosis.The Journal of clinical investigation · 2025Review
- Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care.Clinics in perinatology · 2025Review
- Individualized developmental care interventions for promoting development and preventing morbidity in preterm infants.The Cochrane database of systematic reviews · 2025Article
- Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?Nutrients · 2024Review
- Interorgan rhythmicity as a feature of healthful metabolism.Cell metabolism · 2024Review
- Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device.Frontiers in pediatrics · 2024Article
- The impact of skin-to-skin contact upon stress in preterm infants in a neonatal intensive care unit.Frontiers in pediatrics · 2024Article
- Association between PER and CRY gene polymorphisms and the response to caffeine citrate treatment in infants with apnea of prematurity.Frontiers in pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian system in mammals ensures adaptation to the light-dark cycle on Earth and imposes 24-h rhythmicity on metabolic, physiological and behavioral processes. The central circadian pacemaker is located in the brain and is entrained by environmental signals called Zeitgebers. From here, neural, humoral and systemic signals drive rhythms in peripheral clocks in nearly every mammalian tissue. During pregnancy, disruption of the complex interplay between the mother's rhythmic signals and the fetal developing circadian system can lead to long-term health consequences in the offspring. When an infant is born very preterm, it loses the temporal signals received from the mother prematurely and becomes totally dependent on 24/7 care in the Neonatal Intensive Care Unit (NICU), where day/night rhythmicity is usually blurred. In this literature review, we provide an overview of the fetal and neonatal development of the circadian system, and short-term consequences of disruption of this process as occurs in the NICU environment. Moreover, we provide a theoretical and molecular framework of how this disruption could lead to later-life disease. Finally, we discuss studies that aim to improve health outcomes after preterm birth by studying the effects of enhancing rhythmicity in light and noise exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.