Evidence map›Paper›PMID 37719383›Full record

ArticleActa pharmaceutica Sinica. B2023

Orchestrating antigen delivery and presentation efficiency in lymph node by nanoparticle shape for immune response.

Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng, Zhenzhong Zhang, Lei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  9. Metallic nanomedicine in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongjuan ZhaoSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Yatong LiSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Beibei ZhaoSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Cuixia ZhengSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Mengya NiuSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Qingling SongSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xinxin LiuLuoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 471009, China.
Qianhua FengSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhenzhong ZhangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Lei WangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activating humoral and cellular immunity in lymph nodes (LNs) of nanoparticle-based vaccines is critical to controlling tumors. However, how the physical properties of nanovaccine carriers orchestrate antigen capture, lymphatic delivery, antigen presentation and immune response in LNs is largely unclear. Here, we manufactured gold nanoparticles (AuNPs) with the same size but different shapes (cages, rods, and stars), and loaded tumor antigen as nanovaccines to explore their disparate characters on above four areas. Results revealed that star-shaped AuNPs captured and retained more repetitive antigen epitopes. On lymphatic delivery, both rods and star-shaped nanovaccines mainly drain into the LN follicles region while cage-shaped showed stronger paracortex retention. A surprising finding is that the star-shaped nanovaccines elicited potent humoral immunity, which is mediated by CD4

Indexed as

Antigen captureAntigen presentationCellular immunityHumoral immunityLymphatic deliveryLymph nodeNanoparticle shapeNanovaccines

Identifiers

PMID37719383
PMCPMC10501864

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.