ReviewFrontiers in oral health2023
Oral microbiome as a co-mediator of halitosis and periodontitis: a narrative review.
Review in Frontiers in oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed.
- A Randomized, Double-Blind, Placebo-Controlled Study on Probiotic Treatment for Halitosis: Novel Insights into Glucose and Phosphorus Metabolism.Probiotics and antimicrobial proteins · 2026Trial
- Nd: YAG laser-assisted treatment of subgingival microbiota composition in stage III-IV periodontitis: a randomized controlled study.Clinical oral investigations · 2026Trial
- Article
- Dietary Sulfur Compounds and Halitosis: Bridging Food Science, Microbial Metabolism, and Oral Health: A Comprehensive Review.Molecular nutrition & food research · 2026Review
- Longitudinal shifts in oral microbiome composition and metabolic pathways associated with preterm birth.mSystems · 2026Article
- Site-specific oral microbiome profiles in healthy young Korean women.Scientific reports · 2026Article
- Three Efficacy ofMicroorganisms · 2026Article
- Microbial landscapes in dairy cow diseases: from localized dysbiosis to inter-organ axes.NPJ biofilms and microbiomes · 2026Review
- Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms.Probiotics and antimicrobial proteins · 2026Review
- [Research Progress on Microbiome-Driven Mechanisms and Intervention Strategies for Oral Malodor].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Probiotic intervention modulates volatile sulfur compound-associated pathways and oral microbiome balance in ligature-induced periodontitis rats.Journal of oral microbiology · 2026Article
- Clinical and Microbiological Changes Following Multi-Strain Probiotic Mouthrinse Use in Dental Students with Halitosis: A Prospective Single-Arm Study.Clinical, cosmetic and investigational dentistry · 2026Article
- Control of Dental Plaque and Gingival Inflammation by Natural Ingredients-Based Mouthwash.Dentistry journal · 2025Article
- Microbial changes in different parts of the oral cavity during the early stage of clear aligner treatment: a preliminary study.Clinical oral investigations · 2025Article
- A scientometric study on research trends and characteristics of halitosis.Journal of dental sciences · 2025Article
- Characterisation of the Oral Microbiome in Women With Fibromyalgia: An Observational Case-Control Study.European journal of pain (London, England) · 2025Observational
- Oral microbiota and respiratory diseases: advances and perspectives.Clinical microbiology reviews · 2025Review
- Interaction Between Periodontitis and MASLD: Pathophysiological Associations and Possibilities of Prevention and Therapy.Biomedicines · 2025Review
- Coaggregation of oral pathogens by postbiotic lactobacilli.Journal of oral microbiology · 2025Article
- Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness.Computational and structural biotechnology journal · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Halitosis or oral malodor is an unpleasant odor from the oral cavity. However, although patients with periodontitis often complain of halitosis, their relationship has not been fully elucidated. We reviewed previous literature based on the hypothesis that the relationship between halitosis and periodontitis is mediated by the oral microbiome. Materials and methods: This narrative review sought to provide insight into the causative role of the oral microbiome in influencing halitosis and periodontitis. In addition, we tried to deepen knowledge related to the relationship between halitosis and periodontitis generated by the oral microbiome accumulated over the past 40 years. Results: From 1984 to 2023, a total of 106 papers that carefully and scientifically dealt with halitosis and periodontitis were included in this narrative review. Based on previous results, halitosis and periodontitis were closely related. For decades, researchers have taken an intriguing approach to the question of whether there is a relationship between halitosis and periodontitis. Central factors in the relationship between halitosis and periodontitis include volatile sulfur compounds (VSCs), the oral microbiota that produce VSCs, and the inflammatory response. Conclusions: Taken together, the more severe periodontitis, the higher the level of VSC in halitosis, which may be mediated by oral microbiome. However, the relationship between the occurrence, maintenance, and exacerbation of periodontitis and halitosis is not a necessary and sufficient condition for each other because they are complex interplay even in one individual.
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