ArticleJournal of pain research2023
Polypharmacy and Excessive Polypharmacy Among Persons Living with Chronic Pain: A Cross-Sectional Study on the Prevalence and Associated Factors.
Article in Journal of pain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations Between Multimorbidity, Polypharmacy and Oral Conditions in Older Adults: A Systematic Review and Meta-Analysis.Gerodontology · 2026Pooled it
- VortioxetineCurrent neuropharmacology · 2025Trial
- 3D-printed polypills for personalized medicine and precision oral drug delivery in pharmaceutical practice: A review.International journal of pharmaceutics: X · 2026Review
- Factors Associated with Pain, Disability, and Quality of Life in Adults Aged 18-65 with Nonspecific Chronic Neck Pain: A Single-Center Observational Study.Healthcare (Basel, Switzerland) · 2026Article
- Association between polypharmacy and clinical outcomes in children with medical complexity: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Adenosine AFrontiers in pharmacology · 2026Article
- Sex, gender, and sociodemographic factors associated with repeated prescription refills in chronic pain: insights from a prescription claims cohort study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Pain and Polypharmacy Diminish with Local Treatment of Mesenchymal Stem Cells Following Systemic Modulation of Inflammation: A Case Regarding Diabetic Foot Ulcers.Current issues in molecular biology · 2025Article
- In the Mouth or in the Gut? Innovation Through Implementing Oral and Gastrointestinal Health Science in Chronic Pain Management.Journal of clinical medicine · 2025Article
- Efficacy of NSAIDs and corticosteroids as premedication for post-endodontic pain management: A systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
- Visualizing Real-World Pain Treatment Pathways in Chronic Disease: A Sequence-Based Analysis of Polypharmacy in Systemic Lupus Erythematosus.ACR open rheumatology · 2025Article
- Traditional Korean Medicine Services and Its Association with Knee Surgery and Opioid Use in Patients with Knee Osteoarthritis: A Nationwide Retrospective Study in Korea.Journal of clinical medicine · 2025Article
- Opioid Therapy in Chronic Pain: Assessment of Clinical Outcomes and Relationships With Endocrine Biomarkers.European journal of pain (London, England) · 2025Article
- Assessing the Impact of Pharmacist-Led Interventions in an Academic Pain Clinic: Clinical Outcomes and Interprofessional Insights.European journal of pain (London, England) · 2025Article
- A multicenter cross-sectional study on quality of life and influencing factors in patients with 10 kinds of chronic diseases.Scientific reports · 2025Article
- Physicians' and patients' perceived risks of chronic pain medication and co-medications in Quebec, Canada: a cross-sectional study.BMC primary care · 2025Article
- Association of Pharmacogenotyping and Patient-Reported Outcomes in Chronic Pain Management.Health services insights · 2025Article
- Unpacking excessive polypharmacy patterns among individuals living with chronic pain in Quebec: a longitudinal study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- An association between poor oral health, oral microbiota, and pain identified in New Zealand women with central sensitisation disorders: a prospective clinical study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- The impact of a multidisciplinary team intervention on medication prescription in nursing homes in Catalonia.Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Polypharmacy can be defined as the concomitant use of ≥5 medications and excessive polypharmacy, as the use of ≥10 medications. Objectives were to (1) assess the prevalence of polypharmacy and excessive polypharmacy among persons living with chronic pain, and (2) identify sociodemographic and clinical factors associated with excessive polypharmacy. Patients and Methods: This cross-sectional study used data from 1342 persons from the ChrOnic Pain trEatment (COPE) Cohort (Quebec, Canada). The self-reported number of medications currently used by participants (regardless of whether they were prescribed or taken over-the-counter, or were used for treating pain or other health issues) was categorized to assess polypharmacy and excessive polypharmacy. Results: Participants reported using an average of 6 medications (median: 5). The prevalence of polypharmacy was 71.4% (95% CI: 69.0-73.8) and excessive polypharmacy was 25.9% (95% CI: 23.6-28.3). No significant differences were found across gender identity groups. Multivariable logistic regression revealed that factors associated with greater chances of reporting excessive polypharmacy (vs <10 medications) included being born in Canada, using prescribed pain medications, and reporting greater pain intensity (0-10) or pain relief from currently used pain treatments (0-100%). Factors associated with lower chances of excessive polypharmacy were using physical and psychological pain treatments, reporting better general health/physical functioning, considering pain to be terrible/feeling like it will never get better, and being employed. Conclusion: Polypharmacy is the rule rather than the exception among persons living with chronic pain. Close monitoring and evaluation of the different medications used are important for all persons, especially those with limited access to care.
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