ArticleCNS neuroscience & therapeutics2024
Neurophysiological characterization of stroke recovery: A longitudinal TMS and EEG study.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence.Reviews in the neurosciences · 2024Pooled it
- Electroacupuncture improves upper-limb motor function and modulates sensorimotor network connectivity in subacute stroke: a randomized controlled trial.Frontiers in neurologyTrial
- The Influence of M1 and DLPFC iTBS on BCI Performance: A TMS and fNIRS Study.Translational stroke research · 2026Article
- Functional connectivity associated with severe upper limb impairment in resting-state electroencephalography among chronic stroke survivors: a machine learning approach.Journal of neuroengineering and rehabilitation · 2025Article
- Lightweight EEG Phase Prediction Based on Channel Attention and Spatio-Temporal Parallel Processing.Brain sciences · 2025Article
- Relationship of Interhemispheric Signal Propagation and Severity of Stroke-induced Damage and Unilateral Neglect: A Retrospective Study.Brain topography · 2025Article
- Current implications of EEG and fNIRS as functional neuroimaging techniques for motor recovery after stroke.Medical review (2021) · 2024Review
- Neurophysiological characterization of stroke recovery: A longitudinal TMS and EEG study.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
aimsUnderstanding the neural mechanisms underlying stroke recovery is critical to determine effective interventions for stroke rehabilitation. This study aims to systematically explore how recovery mechanisms post-stroke differ between individuals with different levels of functional integrity of the ipsilesional corticomotor pathway and motor function.
methodsEighty-one stroke survivors and 15 age-matched healthy adults participated in this study. We used transcranial magnetic stimulation (TMS), electroencephalography (EEG), and concurrent TMS-EEG to investigate longitudinal neurophysiological changes post-stroke, and their relationship with behavioral changes. Subgroup analysis was performed based on the presence of paretic motor evoked potentials and motor function.
resultsFunctional connectivity was increased dramatically in low-functioning individuals without elicitable motor evoked potentials (MEPs), which showed a positive effect on motor recovery. Functional connectivity was increased gradually in higher-functioning individuals without elicitable MEP during stroke recovery and influence from the contralesional hemisphere played a key role in motor recovery. In individuals with elicitable MEPs, negative correlations between interhemispheric functional connectivity and motor function suggest that the influence from the contralesional hemisphere may be detrimental to motor recovery.
conclusionOur results demonstrate prominent clinical implications for individualized stroke rehabilitation based on both functional integrity of the ipsilesional corticomotor pathway and motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.