Evidence map›Paper›PMID 37718698›Full record

ArticleMolecular systems biology2023

Turning up the heat on essential E. coli genes.

Arun Kumar, Peter C Stirling

Open access · goldAbstract read
In one paragraph

Article in Molecular systems biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Turning up the heat on essential E. coli genes.Molecular systems biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Arun KumarTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-5676-7521
Peter C StirlingTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0003-2651-4539
Terry Fox Research Institute · CA

Funding

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN 2020-04360
6 · The paper itself

Abstract

Temperature-sensitive (TS) alleles create tunable thermoswitches to deplete essential cellular activities and are used to dissect gene function. In their recent study, Link and colleagues (Schramm et al 2023) use a CRISPR-based approach to systematically create TS alleles across essential genes in E. coli.

Indexed as

Escherichia coliGenes, EssentialAllelesCRISPR-Cas SystemsEscherichia coli ProteinsGene EditingGene Expression Regulation, BacterialHot TemperatureEscherichia coli Proteins

Identifiers

PMID37718698
PMCPMC10568200
OpenAlexW4386817664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.