ArticleThe EMBO journal2023
Infection and inflammation stimulate expansion of a CD74
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Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Paneth Cells: Recent Updates on Elucidating Therapeutic Implications in Gastroenterological Disease Management.Current medicinal chemistry · 2025Pooled it
- Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function.The EMBO journal · 2026Article
- Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.bioRxiv : the preprint server for biology · 2026Article
- Leveraging Single-Cell and Spatial Transcriptomics in Gut Nutrition and Mucosal Immunology.The Journal of nutrition · 2026Article
- Cytokine networks in Paneth cell regulation.Mucosal immunology · 2026Review
- Proinflammatory pathways contribute to the pathogenesis of Clostridioides difficile infection in a murine model using Spatial transcriptomics.Scientific reports · 2025Article
- The gut-heart axis: a correlation between Paneth cells' dysfunction, microbiome dysbiosis, and cardiovascular diseases.Cell communication and signaling : CCS · 2025Review
- Article
- Rab11b is necessary for mitochondrial integrity and function in gut epithelial cells.Frontiers in cell and developmental biology · 2025Article
- Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples.Scientific reports · 2024Article
- Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.Science immunology · 2024Article
- Metabolomic and Transcriptomic Correlative Analyses in Germ-Free Mice Link Lacticaseibacillus rhamnosus GG-Associated Metabolites to Host Intestinal Fatty Acid Metabolism and β-Oxidation.Laboratory investigation; a journal of technical methods and pathology · 2024Article
- Infection and inflammation stimulate expansion of a CD74The EMBO journal · 2023Article
Corrections and comments
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Authors and funding
35 authors at 8 institutions in 3 countries.
Iyshwarya Balasubramanian *Department of Biological Sciences, Rutgers University, Newark, NJ, USA.
Sheila Bandyopadhyay *Department of Biological Sciences, Rutgers University, Newark, NJ, USA.
Juan FloresDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.
Jared Bianchi-SmakDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.
Xiang LinDepartment of Computer Science, New Jersey Institute of Technology, Newark, NJ, USA.
Haoran LiuDepartment of Computer Science, New Jersey Institute of Technology, Newark, NJ, USA.
Shengxiang SunDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0001-5889-3292
Natasha B GolovchenkoCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0001-8323-4643
Yue LiuDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.
Dahui WangDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.ORCID 0009-0002-4345-104X
Radha PatelDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.ORCID 0009-0004-9412-764X
Ivor JosephDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.
Panan SuntornsaratoonDepartment of Pharmacology, Physiology & Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA.
Justin VargasDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0009-5123-9904
Peter Hr GreenDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.
Govind BhagatDepartment of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-6250-048X
Stephen M LaganaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Wang YingHackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ, USA.
Yi ZhangHackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ, USA.ORCID 0000-0002-3456-2728
Zhihan WangDepartment of Statistics, Rutgers University, New Brunswick, NJ, USA.
Wei Vivian LiDepartment of Biostatistics and Epidemiology, Rutgers University, New Brunswick, NJ, USA.ORCID 0000-0002-2087-2709
Sukhwinder SinghDepartment of Pathology, Rutgers New Jersey Medical School, Newark, NJ, USA.
Zhongren ZhouDepartment of Pathology & Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
George KolliasBiomedical Sciences Research Centre, "Alexander Fleming", Vari, Greece.ORCID 0000-0003-1867-3150
Laura A FarrDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
Shannon N MoonahDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
Shiyan YuDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.ORCID 0000-0001-8550-7078
Zhi WeiDepartment of Computer Science, New Jersey Institute of Technology, Newark, NJ, USA.
Edward M BonderDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.
Lanjing ZhangDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.
Pawel R KielaDepartments of Pediatrics and Immunology, and Daniel Cracchiolo Institute for Pediatric Autoimmune Disease Research, Steele Children's Research Center, The University of Arizona Health Sciences, Tucson, AZ, USA.ORCID 0000-0002-0014-3517
Karen L EdelblumCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
Ronaldo FerrarisDepartment of Pharmacology, Physiology & Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA.
Ta-Chiang LiuDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-2800-9360
Nan GaoDepartment of Biological Sciences, Rutgers University, Newark, NJ, USA.ORCID 0000-0003-4264-7438
Rutgers, The State University of New Jersey · USColumbia University Irving Medical Center · USNew Jersey Institute of Technology · USHackensack Meridian Health · USUniversity of Virginia Health System · USWashington University in St. Louis · USAlexander Fleming Biomedical Sciences Research Center · GRUniversity of Arizona · US
Funding
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7MSynthetic rescue of antigen-driven T cells and alloimmunityR01AI143256 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A, ZHANG, YI · 2019 to 2023
$2.9MDOT1L, reconstitution of plasmacytoid dendritic cells and alloimmunityR01HL154757 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ZHANG, YI · 2021 to 2024
$2.6MPaneth cell heterogeneity in infection and inflammationR01DK132885 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI Nan Gao · 2022 to 2026
$2.4MResearch Supplements to Promote Diversity in Health-Related ResearchR01DK119198 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN, KIELA, PAWEL R · 2019 to 2023
$1.9MEndosomal Control of Microbe-Host HomeostasisR01DK102934 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN · 2014 to 2018
$1.8MCD74 and Wound HealingR01DK131313 · NIDDK · UNIVERSITY OF VIRGINIA · PI Shannon Moonah · 2022 to 2026
$1.8MNovel Statistical Methods for Multiscale Analysis of Single-cell TranscriptomesR35GM142702 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LI, WEI VIVIAN · 2021 to 2025
$1.6MScreening and confirmatory machine learning for explainable modeling of non-cancer deaths in cancer patientsR37CA277812 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Lanjing Zhang · 2022 to 2026
$1.6MMucosal modulation by LGG and R. gnavus specific tryptophan metabolitesR01AT010243 · NCCIH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI FERRARIS, RONALDO PARAOAN, GAO, NAN · 2018 to 2021
$1.6MPaneth cell phenotype as a predictive biomarker for ulcerative colitisR01DK124274 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.5MCellular and molecular mechanisms of cigarette smoking-induced Paneth cell abnormalityR01DK125296 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.4MNCCIH NIH HHS R01 AT010243NCI NIH HHS R37 CA277812NHLBI NIH HHS R01 HL154757NIAID NIH HHS R01 AI143256NIAID NIH HHS R21 AI167079NIAID NIH HHS R56 AI143256NIDDK NIH HHS F31 DK121428NIDDK NIH HHS R01 DK102934NIDDK NIH HHS R01 DK119198NIDDK NIH HHS R01 DK124274NIDDK NIH HHS R01 DK125296NIDDK NIH HHS R01 DK131313NIDDK NIH HHS R01 DK132885NIGMS NIH HHS R35 GM142702NIH HHS P40 OD010995
Abstract
Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly recognized as having an essential role in host responses to microbiome and environmental stresses. Whether and how commensal and pathogenic microbes modify PC composition to modulate inflammation remain unclear. Using newly developed PC-reporter mice under conventional and gnotobiotic conditions, we determined PC transcriptomic heterogeneity in response to commensal and invasive microbes at single cell level. Infection expands the pool of CD74
Indexed as
MicrobiotaPaneth CellsAnimalsCytokinesHumansInflammationIntestine, SmallMiceCytokinesCD74heterogeneitylysozymeLyz1Paneth cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.