SynthesisRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2024
Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis.
Synthesis in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Psychotropic Use Among Classroom Teachers in Espírito Santo: A Cross-Sectional Study.Pharmacoepidemiology and drug safety · 2026Article
- Uncovering antidepressant prescription patterns: a three-year analysis of outpatient trends.BMC psychiatry · 2025Article
- Response to "Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis".Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Psychiatric drugs dispensing trends in the affected population following Brumadinho dam failure.Frontiers in public health · 2025Article
- The use of psychiatric medications and associated factors among people receiving care at a transgender outpatient clinic in Southern Brazil, 2021-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo estimate the prevalence of antidepressant use in Brazil.
methodsWe conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data, and assessed the methodological quality. We pooled the prevalence of antidepressant use using meta-analyses of proportions (Freeman-Tukey transformation) and estimated heterogeneity by the I2 statistic. OR meta-analyses of antidepressant use by sex were calculated (men as reference) and between-study variation was explored by meta-regressions.
resultsOut of 3,299 records retrieved, 23 studies published in 28 reports were included, with a total of 75,061 participants. The overall prevalence of antidepressant use was 4.0% (95%CI 2.7-5.6%; /² = 98.5%). Use of antidepressants in the previous 3 days was higher in women (12.0%; 95%CI 9.5-15.1%; /² = 0%) than men (4.6%; 95%CI 3.1-6.8%; /² = 0%) (p < 0.001; OR = 2.82; 95%CI 1.72-4.62). Gender differences were particularly higher for antidepressant use in the previous year (women: 2.3%; 95%CI 1.6-3.1; /² = 37.6% vs. men: 0.5%; 95%CI 0.2-1.0%; /² = 0%, p < 0.001; OR = 4.18; 95%CI 2.10-8.30). Between-study variation in the overall prevalence of antidepressant use significantly increased with mean participant age (p = 0.035; residual /² = 0%; regression coefficient = 0.003).
conclusionFour out of every 100 Brazilians used antidepressants in this 3-decade assessment. Use increased with age and was more prevalent in women compared to men. REGISTRATION NUMBER: PROSPERO CRD42022345332.
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