Evidence map›Paper›PMID 37718134›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2024

White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?

Andrew R Gerlach, Helmet T Karim, Soyoung Lee, Antonija Kolobaric, Dana L Tudorascu, Meryl A Butters, Carmen Andreescu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew R GerlachDepartment of Psychiatry (ARG, HTK, DLT, MAB, CA), University of Pittsburgh, Pittsburgh, PA.
Helmet T KarimDepartment of Psychiatry (ARG, HTK, DLT, MAB, CA), University of Pittsburgh, Pittsburgh, PA; Department of Bioengineering (HTK), University of Pittsburgh, Pittsburgh, PA.
Soyoung LeeDepartment of Psychiatry (SL), Brigham and Women's Hospital, Boston, MA; Department of Psychiatry (SL), Harvard Medical School, Boston, MA.
Antonija KolobaricCenter for Neuroscience (AK), University of Pittsburgh, Pittsburgh, PA.
Dana L TudorascuDepartment of Psychiatry (ARG, HTK, DLT, MAB, CA), University of Pittsburgh, Pittsburgh, PA; Department of Biostatistics (DLT), University of Pittsburgh, Pittsburgh, PA.
Meryl A ButtersDepartment of Psychiatry (ARG, HTK, DLT, MAB, CA), University of Pittsburgh, Pittsburgh, PA.
Carmen AndreescuDepartment of Psychiatry (ARG, HTK, DLT, MAB, CA), University of Pittsburgh, Pittsburgh, PA. Electronic address: andrcx@upmc.edu.
University of Pittsburgh · USBrigham and Women's Hospital · US

Funding

Mild Cognitive Impairment: A Prospective Community StudyR01AG023651 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GANGULI, MARY · 2005 to 2020
$27.1M
The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia RiskR01MH108509 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Carmen Andreescu · 2016 to 2026
$10.6M
Pharmacologic MRI Predictors of Treatment Response in Late-Life DepressionR01MH076079 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, ANDREESCU, CARMEN · 2006 to 2022
$7.1M
CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERST32MH019986 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Carmen Andreescu · 1997 to 2026
$6.9M
Recurrence markers, cognitive burden and neurobiological homeostasis in latelife depression (REMBRANDT) - SupplementR01MH121619 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANDREESCU, CARMEN · 2020 to 2024
$5.1M
Population Neuroscience of Aging and Alzheimer's Disease (PNA)T32AG055381 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano, Andrea L Rosso · 2018 to 2026
$2.7M
NIA NIH HHS R01 AG023651NIA NIH HHS T32 AG055381NIMH NIH HHS R01 MH076079NIMH NIH HHS R01 MH108509NIMH NIH HHS R01 MH121619NIMH NIH HHS T32 MH019986
6 · The paper itself

Abstract

objectiveWe investigated the relationship between anxiety phenotypes (global anxiety, worry, and rumination) and white matter hyperintensities (WMH), with special consideration for the roles of age and executive function (EF). Our hypotheses were 1) anxiety phenotypes would be associated with WMH and 2) EF would moderate this relationship.

designCross-sectional.

settingParticipants were recruited from the local community (Pittsburgh, PA).

participantsWe recruited 110 older adults (age ≥ 50) with varying worry severity and clinical comorbidity.

interventionsNot applicable. MEASUREMENTS: Demographics (age, sex, race, education), clinical measures (cumulative illness burden, global anxiety, worry, and rumination), EF, and WMH quantified with magnetic resonance imaging.

resultsLower global anxiety and worry severity were significantly correlated with higher WMH volume, though the global anxiety relationship was not significant after controlling for age. Rumination as not associated with WMH burden. EF was not correlated with either global anxiety, worry, rumination, or WMH. However, in those with advanced age and/or greater WMH burden, there was an association between worry and EF as well as EF and WMH.

conclusionLongitudinal studies are needed in order to clarify the complex interactions between anxiety phenotypes, WMH, and EF.

Indexed as

White MatterAgedAnxietyCross-Sectional StudiesExecutive FunctionHumansMagnetic Resonance Imaginganxietyexecutive functionlate Lifewhite matter hyperintensitiesWorry

Identifiers

PMID37718134
PMCPMC10843002
OpenAlexW4386202574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.