Evidence map›Paper›PMID 37718000›Full record

ArticleVitamins and hormones2023

Juvenile hormone receptor Methoprene tolerant: Functions and applications.

Subba Reddy Palli

Open access · greenAbstract read
In one paragraph

Article in Vitamins and hormones, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Juvenile hormone receptor relies on conserved domain interfaces for dimerization-dependent activity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Ontogenetic variability of the Siberian silk moth,Frontiers in insect science · 2026
    Article
  5. Membrane-localized MET engages PVR to mediate extranuclear juvenile hormone signaling inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. ame-miR-5119-Frontiers in physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Subba Reddy PalliDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, United States. Electronic address: rpalli@uky.edu.
University of Kentucky · US

Funding

Molecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1M
Molecular mode of action of Juvenile hormone analogsR21AI163561 · NIAID · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2021 to 2022
$399k
RNAi methods for Zika virus vector controlR21AI131427 · NIAID · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2017 to 2018
$385k
NIAID NIH HHS R21 AI131427NIAID NIH HHS R21 AI163561NIGMS NIH HHS R01 GM070559
6 · The paper itself

Abstract

During the past 15years, after confirming Methoprene tolerant (Met) as a juvenile hormone (JH) receptor, tremendous progress has been made in understanding the function of Met in supporting JH signal transduction. Met role in JH regulation of development, including metamorphosis, reproduction, diapause, cast differentiation, behavior, im`munity, sleep and epigenetic modifications, have been elucidated. Met's Heterodimeric partners involved in performing some of these functions were discovered. The availability of JH response elements (JHRE) and JH receptor allowed the development of screening assays in cell lines and yeast. These screening assays facilitated the identification of new chemicals that function as JH agonists and antagonists. These new chemicals and others that will likely be discovered in the near future by using JH receptor and JHRE will lead to highly effective species-specific environmentally friendly insecticides for controlling pests and disease vectors.

Indexed as

Juvenile HormonesMethopreneCell DifferentiationEpigenesis, GeneticHumansReproductionJuvenile HormonesMethopreneCRISPR/Cas9GceGenome editingJHMetRNAiTaiman

Identifiers

PMID37718000
PMCPMC12449589
OpenAlexW4378551768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.