Evidence map›Paper›PMID 37717626›Full record

ReviewThe Journal of allergy and clinical immunology2024

The role of glycosylation in clinical allergy and immunology.

Rebecca C Hale, Dominique Morais, Janet Chou, Sean R Stowell

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. T Cell O-GlcNAcylation Increases in Patients With Allergic Rhinitis After the Natural Pollen Season.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  2. Revealing the Biological Effect of theJournal of the American Chemical Society · 2026
    Article
  3. Review
  4. Article
  5. Safety Aspects of Cell Culture-Derived Food for Human Consumption.Advances in biochemical engineering/biotechnology · 2026
    Review
  6. Use of Microbial Microarrays to Define Antibody Specificity.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. IntegratingCurrent research in food science · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rebecca C HaleDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Dominique MoraisDepartment of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Janet ChouDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: janet.chou@childrens.harvard.edu.
Sean R StowellDepartment of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Harvard Glycomics Center, Harvard Medical School, Boston, Mass. Electronic address: srstowell@bwh.harvard.edu.
Brigham and Women's Hospital · USBoston Children's Hospital · US

Funding

MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
Examination of Initiating Factors that Regulate Red Blood Cell AlloimmunizationR01HL135575 · NHLBI · EMORY UNIVERSITY · PI Sean R Stowell · 2017 to 2026
$2.8M
Impact of Anemia and Its Treatment on Gut Injury in Preterm InfantsR01HL138714 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JOSEPHSON, CASSANDRA D, STOWELL, SEAN R · 2020 to 2023
$2.8M
Examining Immune Circuits Responsible for Anamnestic RBC AlloimmunizationR01HL165975 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI STOWELL, SEAN R · 2022 to 2025
$2.4M
NHLBI NIH HHS R01 HL135575NHLBI NIH HHS R01 HL138714NHLBI NIH HHS R01 HL165975NIAID NIH HHS T32 AI007512
6 · The paper itself

Abstract

While glycans are among the most abundant macromolecules on the cell with widespread functions, their role in immunity has historically been challenging to study. This is in part due to difficulties assimilating glycan analysis into routine approaches used to interrogate immune cell function. Despite this, recent developments have illuminated fundamental roles for glycans in host immunity. The growing field of glycoimmunology continues to leverage new tools and approaches to uncover the function of glycans and glycan-binding proteins in immunity. Here we utilize clinical vignettes to examine key roles of glycosylation in allergy, inborn errors of immunity, and autoimmunity. We will discuss the diverse functions of glycans as epitopes, as modulators of antibody function, and as regulators of immune cell function. Finally, we will highlight immune modulatory therapies that harness the critical role of glycans in the immune system.

Indexed as

HypersensitivityAntibodiesGlycosylationHumansImmune SystemPolysaccharidesAntibodiesPolysaccharidesantibody glycosylationGlycosylationimmunomodulationimmunotherapyPGM3

Identifiers

PMID37717626
PMCPMC10872775
OpenAlexW4386814072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.