Evidence map›Paper›PMID 37717209›Full record

ReviewAdvanced healthcare materials2024

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents.

Manja Kubeil, Yota Suzuki, Maria Antonietta Casulli, Rozy Kamal, Takeshi Hashimoto, Michael Bachmann, Takashi Hayashita, Holger Stephan

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manja KubeilHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research Bautzner Landstraße 400, 01328, Dresden, Germany.ORCID 0000-0001-8857-5922
Yota SuzukiGraduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-Ku, Saitama, 338-8570, Japan.ORCID 0000-0002-6182-8042
Maria Antonietta CasulliMicro and Nano Systems (MNS), Kasteelpark Arenberg 10, Leuven, Heverlee, 3001, Belgium.ORCID 0000-0002-9948-1427
Rozy KamalDepartment of Nuclear Medicine, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.ORCID 0000-0002-3207-3250
Takeshi HashimotoFaculty of Science & Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102-8554, Japan.ORCID 0000-0002-7601-5511
Michael BachmannHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research Bautzner Landstraße 400, 01328, Dresden, Germany.ORCID 0000-0002-8029-5755
Takashi HayashitaFaculty of Science & Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102-8554, Japan.ORCID 0000-0003-1264-9694
Holger StephanHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research Bautzner Landstraße 400, 01328, Dresden, Germany.ORCID 0000-0002-2972-2803

Funding

Helmholtz Initiative and Networking Fund InterLabs-0031Japan Society for the Promotion of Science 21J00709Japan Society for the Promotion of Science 22KJ2748JSPS Grant-in-Aid for Scientific Research 20H02772JSPS Grant-in-Aid for Scientific Research 21K03452JSPS Grant-in-Aid for Scientific Research 23K04792
6 · The paper itself

Abstract

Nanogels open up access to a wide range of applications and offer among others hopeful approaches for use in the field of biomedicine. This review provides a brief overview of current developments of nanogels in general, particularly in the fields of drug delivery, therapeutic applications, tissue engineering, and sensor systems. Specifically, cyclodextrin (CD)-based nanogels are important because they have exceptional complexation properties and are highly biocompatible. Nanogels as a whole and CD-based nanogels in particular can be customized in a wide range of sizes and equipped with a desired surface charge as well as containing additional molecules inside and outside, such as dyes, solubility-mediating groups or even biological vector molecules for pharmaceutical targeting. Currently, biological investigations are mainly carried out in vitro, but more and more in vivo applications are gaining importance. Modern molecular imaging methods are increasingly being used for the latter. Due to an extremely high sensitivity and the possibility of obtaining quantitative data on pharmacokinetic and pharmacodynamic properties, nuclear methods such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) using radiolabeled compounds are particularly suitable here. The use of radiolabeled nanogels for imaging, but also for therapy, is being discussed.

Indexed as

CyclodextrinsDrug CarriersDrug Delivery SystemsNanogelsRadiopharmaceuticalsTomography, X-Ray ComputedCyclodextrinsDrug CarriersNanogelsRadiopharmaceuticalscyclodextrindrug deliverymolecular imagingnanogelsradiolabelingtheranostics

Identifiers

PMID37717209
PMCPMC11468994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.