Evidence map›Paper›PMID 37717031›Full record

ArticleNature communications2023

Structural insights into functional properties of the oxidized form of cytochrome c oxidase.

Izumi Ishigami, Raymond G Sierra, Zhen Su, Ariana Peck, Cong Wang, Frederic Poitevin, Stella Lisova, Brandon Hayes, Frank R Moss, Sébastien Boutet and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Adaptation of OXPHOS biogenesis to cellular requirements.Protein science : a publication of the Protein Society · 2026
    Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Structural and functional mechanisms of cytochrome c oxidase.Journal of inorganic biochemistry · 2025
    Review
  17. Similarity between oxygen evolution in photosystem II and oxygen reduction in cytochrome c oxidase via proton coupled electron transfers. A unified view of the oxygenic life from four electron oxidation-reduction reactions.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  18. Review
  19. Membrane-Bound Redox Enzyme CytochromeInternational journal of molecular sciences · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Izumi IshigamiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.ORCID http://orcid.org/0000-0001-6929-1908
Raymond G SierraLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0002-6253-8282
Zhen SuLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Ariana PeckLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Cong WangLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Frederic PoitevinLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Stella LisovaLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Brandon HayesLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Frank R MossLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Sébastien BoutetLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0003-3928-1244
Robert E SublettLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Chun Hong YoonLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0003-1482-1662
Syun-Ru YehDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. syun-ru.yeh@einsteinmed.edu.ORCID http://orcid.org/0000-0002-9858-386X
Denis L RousseauDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. denis.rousseau@einsteinmed.edu.ORCID http://orcid.org/0000-0001-5405-5128

Funding

Structural Dynamics at LCLSP41GM139687 · NIGMS · STANFORD UNIVERSITY · PI HUNTER, MARK · 2021 to 2025
$7.5M
Structure and Function of Heme-based DioxygenasesR01GM115773 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI YEH, SYUN-RU · 2016 to 2023
$3.3M
Structures of time-resolved intermediates in cytochrome c oxidase obtained by serial femtosecond crystallographyR01GM126297 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DENIS L. ROUSSEAU · 2017 to 2026
$3.2M
High-end X-ray Detector System for Femtosecond CrystallographyS10OD023453 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2017 to 2017
$1.7M
NIGMS NIH HHS P41 GM139687NIGMS NIH HHS R01 GM115773NIGMS NIH HHS R01 GM126297NIH HHS S10 OD023453
6 · The paper itself

Abstract

Cytochrome c oxidase (CcO) is an essential enzyme in mitochondrial and bacterial respiration. It catalyzes the four-electron reduction of molecular oxygen to water and harnesses the chemical energy to translocate four protons across biological membranes. The turnover of the CcO reaction involves an oxidative phase, in which the reduced enzyme (R) is oxidized to the metastable O

Indexed as

Electron Transport Complex IVProtonsCell MembraneCrystallography, X-RayOxygenElectron Transport Complex IVOxygenProtons

Identifiers

PMID37717031
PMCPMC10505203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.