Evidence map›Paper›PMID 37716927›Full record

ArticleCellular and molecular neurobiology2023

Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia.

Pavel Tregub, Yuri Motin, Vladimir Kulikov, Pavel Kovzelev, Aleksandra Chaykovskaya, Irada Ibrahimli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Pavel TregubDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, Trubetskaya Str., 8, P. 2, Moscow, Russian Federation, 119991. tregub_p_p@staff.sechenov.ru.ORCID http://orcid.org/0000-0002-3650-6121
Yuri MotinAltai State Medical University, 40 Lenin Prospekt, Barnaul, Russian Federation, 656038.ORCID http://orcid.org/0000-0003-4282-6401
Vladimir KulikovAltai State Medical University, 40 Lenin Prospekt, Barnaul, Russian Federation, 656038.ORCID http://orcid.org/0000-0003-4869-5465
Pavel KovzelevV.A. Almazov National Medical Research Center, Akkuratov Str., P. 2, St. Petersburg, Russian Federation, 197341.ORCID http://orcid.org/0000-0003-1430-3195
Aleksandra ChaykovskayaV.A. Almazov National Medical Research Center, Akkuratov Str., P. 2, St. Petersburg, Russian Federation, 197341.ORCID http://orcid.org/0000-0003-1140-8039
Irada IbrahimliDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, Trubetskaya Str., 8, P. 2, Moscow, Russian Federation, 119991.ORCID http://orcid.org/0009-0001-9032-517X
Altai State Medical University · RUFederal Almazov North-West Medical Research Centre · RUPeoples' Friendship University of Russia · RUSechenov University · RU

Funding

RUDN University project № 210500-2-000
6 · The paper itself

Abstract

Isolated exposure to intermittent hypoxia and permissive hypercapnia activates signaling mechanisms that induce ultrastructural changes in mitochondria and endoplasmic reticulum, accompanied by the development of maximal ischemic tolerance in neurons under the combined influence of these factors. However, there are a lack of data on the combined impact of these factors on the ultrastructure of neuronal organelles. The present study aims to comparatively assess the ultrastructural changes in neurons following isolated and combined exposure to hypoxia and hypercapnia, as well as to correlate these changes with the neuroprotective potential previously observed for these factors. Following a 15-session course of 30-min exposures to permissive hypercapnia (P

Indexed as

HypercapniaHypoxiaCerebral CortexHippocampusHumansNeuronsAdaptationHypercapniaHypercapnic hypoxiaHypoxiaNeuroprotectionUltrastructural neurons

Identifiers

PMID37716927
PMCPMC11407706
OpenAlexW4386798826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.