Evidence map›Paper›PMID 37716650›Full record

ArticleThe Journal of investigative dermatology2024

Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides.

Zizi Yu, Pablo Vieyra-Garcia, Theresa Benezeder, Jack D Crouch, Ira R Kim, John T O'Malley, Phillip M Devlin, Ahmed Gehad, Qian Zhan, Johann E Gudjonsson and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 2 countries.

Zizi YuDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Pablo Vieyra-GarciaResearch Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
Theresa BenezederResearch Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
Jack D CrouchDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ira R KimDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
John T O'MalleyDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phillip M DevlinDepartment of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Ahmed GehadDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Qian ZhanDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Mrinal K SarkarDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
J Michelle KahlenbergDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Nega GerardDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jessica E TeagueDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Thomas S KupperDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Nicole R LeBoeufDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Cecilia LaroccaDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Marianne TawaCenter for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Bohdan PomahacDivision of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
Simon G TalbotDivision of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dennis P OrgillDivision of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Peter WolfResearch Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. Electronic address: peter.wolf@medunigraz.at.
Rachael A ClarkDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: rclark@bwh.harvard.edu.
Brigham and Women's Hospital · USMedical University of Graz · ATUniversity of Michigan · USHarvard University · USYale University · US

Funding

The Next Generation Immunoanalysis CoreP30AR069625 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN · 2016 to 2025
$8.8M
DERMATOLOGY TRAINING GRANTT32AR007098 · NIAMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI THOMAS S. KUPPER · 1986 to 2026
$8.1M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Skin Homing T CellsR01AR065807 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUPPER, THOMAS S. · 2013 to 2022
$6.3M
Transforming the diagnosis and care of patients with CTCL using TCR sequencingR01CA203721 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN, KUPPER, THOMAS S. · 2016 to 2020
$3.4M
Optimizing pre-analytic sample handling for high throughput TCR sequencing in cutaneous T cell lymphomaU01CA253190 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN · 2020 to 2024
$2.1M
Reversing immune evasion and enhancing immune detection with topical resiquimodR01AR074797 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN, ROOK, ALAIN H · 2018 to 2021
$1.9M
NCI NIH HHS R01 CA203721NCI NIH HHS U01 CA253190NIAMS NIH HHS P30 AR069625NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR065807NIAMS NIH HHS R01 AR074797NIAMS NIH HHS T32 AR007098
6 · The paper itself

Abstract

Transcriptional profiling demonstrated markedly reduced type I IFN gene expression in untreated mycosis fungoides (MF) skin lesions compared with that in healthy skin. Type I IFN expression in MF correlated with antigen-presenting cell-associated IRF5 before psoralen plus UVA therapy and epithelial ULBP2 after therapy, suggesting an enhancement of epithelial type I IFN. Immunostains confirmed reduced baseline type I IFN production in MF and increased levels after psoralen plus UVA treatment in responding patients. Effective tumor clearance was associated with increased type I IFN expression, enhanced recruitment of CD8

Indexed as

FurocoumarinsMycosis FungoidesSkin NeoplasmsCD8-Positive T-LymphocytesGene ExpressionHumansPhototherapyFurocoumarins

Identifiers

PMID37716650
PMCPMC10922223
OpenAlexW4386790096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.