Evidence map›Paper›PMID 37716507›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2023

Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment.

Andrea Gillis, Rui Zheng-Pywell, Chandler McLeod, Dezhi Wang, John M Ness, Rachael Guenter, Jason Whitt, Tomas A Prolla, Herbert Chen, Manuel Lora Gonzalez and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Dual-tracerFrontiers in endocrinology · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Andrea GillisDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Rui Zheng-PywellDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Chandler McLeodDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Dezhi WangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
John M NessDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Rachael GuenterDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Jason WhittDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Tomas A ProllaDepartment of Medical Genetics, University of Wisconsin, Madison, Wisconsin.
Herbert ChenDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Manuel Lora GonzalezDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Bart RoseDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Ricardo V LloydDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconin.
Renata Jaskula-SztulDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: rjsztul@uabmc.edu.
Diana LinDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: dmlin@uab.edu.
University of Alabama at Birmingham · USUniversity of Wisconsin–Madison · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UPENDER MANNE, Erica Michelle Stringer-Reasor · 2005 to 2026
$26.6M
NCATS NIH HHS UL1 TR003096NCI NIH HHS P30 CA013148NCI NIH HHS U54 CA118948
6 · The paper itself

Abstract

Somatostatin receptor type 2 (SSTR2) and thyroid-stimulating hormone receptor (TSHR) display variable expression in primary thyroid tumors and have been implicated as theranostic targets. This study was designed to explore the differential expression of SSTR2 and TSHR in oncocytic (Hurthle cell) carcinoma (OC) vs oncocytic adenoma (OA). We performed a retrospective review for oncocytic neoplasms treated at our institution from 2012 to 2019. Formalin-fixed paraffin-embedded tissue blocks were used for tissue microarray construction. Tissue microarray blocks were cut into 5-μm sections and stained with anti-SSTR2 and anti-TSHR antibodies. Immunostains were analyzed by 3 independent pathologists. χ

Indexed as

Neoplasms, Glandular and EpithelialThyroid NeoplasmsFemaleHumansMaleMiddle AgedPrognosisReceptors, SomatostatinReceptors, ThyrotropinThyrotropinReceptors, SomatostatinReceptors, Thyrotropinsomatostatin receptor 2Thyrotropinimmunohistochemistryoncocytic carcinomasomatostatin receptorthyroid cancerthyroid-stimulating hormone receptor

Identifiers

PMID37716507
PMCPMC10843045
OpenAlexW4386784616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.