Evidence map›Paper›PMID 37716474›Full record

ArticleChest2024

Evaluation of the Double-Tracer Gas Single-Breath Washout Test in a Pediatric Field Study.

Anne-Christianne Kentgens, Johanna M Kurz, Rebeca Mozun, Jakob Usemann, Eva S L Pedersen, Claudia E Kuehni, Philipp Latzin, Alexander Moeller, Florian Singer, LuftiBus In the School (LUIS) Study Group

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03659838 (Luftibus in the School), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03659838 completednot on this map

Luftibus in the School: a Population-based Study of Respiratory Symptoms, Lung Function and Air Pollution.

TypeobservationalSponsorUniversity Children's Hospital, ZurichRan2013 to 2016Enrolled3,500ConditionsRespiratory Disease
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 4 countries.

Anne-Christianne KentgensDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Johanna M KurzDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Rebeca MozunInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Department of Intensive Care and Neonatology and Children's Research Center, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.
Jakob UsemannDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Respiratory Medicine, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland; University Children's Hospital Basel (UKBB), Basel, Switzerland.
Eva S L PedersenInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Claudia E KuehniDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Philipp LatzinDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Alexander MoellerDepartment of Respiratory Medicine, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.
Florian SingerDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Respiratory Medicine, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland; Division of Pediatric Pulmonology and Allergology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. Electronic address: florian.singer@uzh.ch.
LuftiBus In the School (LUIS) Study Group
University of Bern · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe early life origins of chronic pulmonary diseases are thought to arise in peripheral small airways. Predictors of ventilation inhomogeneity, a proxy of peripheral airway function, are understudied in schoolchildren. RESEARCH QUESTION: Is the double-tracer gas single-breath washout (DTG-SBW) measurement feasible in a pediatric field study setting? What are the predictors of the DTG-SBW-derived ventilation inhomogeneity estimate in unselected schoolchildren? STUDY DESIGN AND

methodsIn this prospective cross-sectional field study, a mobile lung function testing unit visited participating schools in Switzerland. We applied DTG-SBW, fraction of exhaled nitric oxide (Feno), and spirometry measurements. The DTG-SBW is based on tidal inhalation of helium and sulfur-hexafluoride, and the phase III slope (SIII

resultsIn 1,782 children, 5,223 DTG-SBW trials were obtained. The DTG-SBW was acceptable in 1,449 children (81.3%); the coefficient of variation was 39.8%. SIII

interpretationThe DTG-SBW is feasible in a pediatric field study setting. On the population level, age, body composition, and wheeze are independent predictors of peripheral airway function in unselected schoolchildren. The variation of the DTG-SBW possibly constrains its current applicability on the individual level.

trial registrationClinicalTrials.gov; No.: NCT03659838; URL: www. CLINICALTRIALS: gov.

Indexed as

GasesRespirationBreath TestsChildCross-Sectional StudiesHumansProspective StudiesSulfur HexafluorideGasesSulfur Hexafluorideadolescentchildheliumlung function testssmall airway remodelingsulfur hexafluorideventilation testswheezing

Identifiers

PMID37716474
PMCPMC10851274
OpenAlexW4386790852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.