Evidence map›Paper›PMID 37715489›Full record

ArticleActa biochimica et biophysica Sinica2023

CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.

Di Wu, Jiahui Zhu, Fang Yang, Riwang Li, Lexin Liu, Dahai Liu, Chi Liu, Xiangping Qu, Huijun Liu, Ming Ji and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Di WuSchool of Medicine, Foshan University, Foshan 528000, China.
Jiahui ZhuDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Fang YangSchool of Medicine, Foshan University, Foshan 528000, China.
Riwang LiSchool of Medicine, Foshan University, Foshan 528000, China.
Lexin LiuDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Dahai LiuSchool of Medicine, Foshan University, Foshan 528000, China.
Chi LiuDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Xiangping QuDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Huijun LiuDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Ming JiDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Xiaoqun QinDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Lan Huathe Second Xiangya Hospital of Central South University, Changsha 410011, China.
Yang XiangDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha 410008, China.
Central South University · CNFoshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The downregulation of adhesion molecule catenin alpha-like 1 (CTNNAL1) in airway epithelial cells of asthma patients and house dust mite (HDM)-induced asthma animal models was illustrated in our previous study. It is assumed to contribute to airway inflammation and mucus hypersecretion. In this work, we further explore the underlying mechanism of CTNNAL1 in asthma.

Indexed as

AsthmaCystic Fibrosis Transmembrane Conductance Regulatoralpha CateninAnimalsDisease Models, AnimalEpithelial CellsFemaleHumansMicePyroglyphidaerho-Associated KinasesSignal Transductionalpha CateninCTNNAL1 protein, humanCTNNAL1 protein, mouseCystic Fibrosis Transmembrane Conductance Regulatorrho-Associated KinasesROCK1 protein, humanasthmaCALCFTRCTNNAL1ROCK1

Identifiers

PMID37715489
PMCPMC10579809
OpenAlexW4385308725

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.