Evidence map›Paper›PMID 37715342›Full record

ArticleCPT: pharmacometrics & systems pharmacology2023

Mechanistic modeling projections of antibody persistence after homologous booster regimens of COVID-19 vaccine Ad26.COV2.S in humans.

Anna Dari, Philippe Jacqmin, Yuki Iwaki, Martine Neyens, Mathieu Le Gars, Jerald Sadoff, Karin Hardt, Javier Ruiz-Guiñazú, Juan José Pérez-Ruixo

Open access · goldAbstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Anna DariJanssen Research & Development, Beerse, Belgium.ORCID 0000-0001-6972-4902
Philippe JacqminMnS Modeling and Simulation, Dinant, Belgium.
Yuki IwakiJanssen Pharmaceutical K.K., Tokyo, Japan.
Martine NeyensJanssen Research & Development, Beerse, Belgium.
Mathieu Le GarsJanssen Vaccines & Prevention, Leiden, The Netherlands.
Jerald SadoffJanssen Vaccines & Prevention, Leiden, The Netherlands.
Karin HardtJanssen Research & Development, Beerse, Belgium.
Javier Ruiz-GuiñazúJanssen Research & Development, Beerse, Belgium.ORCID 0000-0001-6941-3100
Juan José Pérez-RuixoJanssen Research & Development, Beerse, Belgium.ORCID 0000-0001-9890-745X
Janssen (Belgium) · BEJanssen (Netherlands) · NLSystem Simulation (United Kingdom) · GB

Funding

ASPR HHS HHSO100201700018C
6 · The paper itself

Abstract

Mechanistic model-based simulations can be deployed to project the persistence of humoral immune response following vaccination. We used this approach to project the antibody persistence through 24 months from the data pooled across five clinical trials in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-seronegative participants following vaccination with Ad26.COV2.S (5 × 10

Indexed as

Ad26COVS1COVID-19Antibodies, NeutralizingCOVID-19 VaccinesFemaleHumansMaleSARS-CoV-2Ad26COVS1Antibodies, NeutralizingCOVID-19 Vaccines

Identifiers

PMID37715342
PMCPMC10583247
OpenAlexW4386796119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.