ArticleEuropean journal of medical research2023
Prophylactic antibiotics for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Effectiveness of antibiotic prophylaxis for ventilator-associated pneumonia in acute brain injury: a systematic review and meta-analysis.Infection · 2026Pooled it
- Practices and Perceptions of Infectious Diseases and Critical Care Clinicians Regarding Aerosolized Antimicrobial Therapy in the State of Qatar: A Multicenter Cross-Sectional Study.Antibiotics (Basel, Switzerland) · 2026Article
- Bayesian network model for identification of factors associated with ventilator-associated pneumonia in mechanically ventilated patients in the ICU: retrospective cohort study.BMC pulmonary medicine · 2026Article
- Challenges in Antimicrobial Treatment and Antimicrobial Stewardship in Hospital-Acquired Infections in Adult Burn Patients.European burn journal · 2026Review
- Inhibition of <italic>Pseudomonas aeruginosa</italic> Biofilm Formation by Peptidyl-Arginine Deiminases 2 and 4.Journal of innate immunity · 2026Article
- Inhaled amikacin as a preventive strategy against ventilator-associated pneumonia in a trauma intensive care unit: early evidence from a single-center retrospective cohort study.Journal of trauma and injury · 2025Article
- Nebulized Antibiotics for Preventing and Treating Gram-Negative Respiratory Infections in Critically Ill Patients: An Overview of Reviews.Antibiotics (Basel, Switzerland) · 2025Review
- Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Oral care medications for the prevention and treatment of ventilator-associated pneumonia in intensive care unit.Frontiers in oral health · 2025Review
- Evaluating the Efficacy of Inhaled Colistin via Two Nebulizer Types in Ventilator-Associated Pneumonia: Prospective Randomized Trial.Antibiotics (Basel, Switzerland) · 2024Article
- Antibiofilm Strategies in Neonatal and Pediatric Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models.BMC neuroscience · 2024Review
- Prevention of ventilator-associated pneumonia with inhaled antibiotics.World journal of emergency medicine · 2024Article
- The Role of Systemic Antibiotics in Preventing Ventilator-associated Pneumonia in Intensive Care Unit Patients: Insights from a Systematic Review and Meta-analysis.Journal of research in pharmacy practiceReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of prophylactic antibiotics in preventing ventilator-associated pneumonia (VAP) in patients undergoing invasive mechanical ventilation (IMV) remains unclear. This network meta-analysis compared the efficacy and safety of antibiotic prophylaxis in preventing VAP in an IMV population in intensive-care units (ICUs).
methodsWe searched the PubMed, Web of Science, Embase, and Cochrane Library databases from inception to December 2021, to identify relevant studies assessing the impact of prophylactic antibiotics on the incidence of VAP, the mortality, and the duration of ICU stays and hospitalization to perform a meta-analysis.
resultsThirteen studies (2144 patients) were included, 12 of which were selected for the primary analysis, which revealed that treatment with prophylactic antibiotics resulted in a lower VAP rate compared with control groups [risk ratio (RR) = 0.62]. Bayesian network meta-analysis indicated that aerosolized tobramycin and intravenous ampicillin-sulbactam presented the greatest likelihood being the most efficient regimen for reducing VAP.
conclusionsAntibiotic prophylaxis may reduce the incidence of VAP, but not the mortality, for adult patients undergoing IMV in ICUs. Tobramycin via nebulization and ampicillin-sulbactam via intravenous administration presented the greatest likelihood of being the most efficient regimen for preventing VAP. However, well-designed randomized studies are warranted before definite recommendations can be made.
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