ArticleHypertension research : official journal of the Japanese Society of Hypertension2024
Home systolic blood pressure time in therapeutic range and cardiovascular risk: the practitioner-based nationwide J-HOP study extended.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis.European heart journal · 2025Pooled it
- Association of Systolic Blood Pressure Time in Target Range With Cardiovascular Events Among PRECISION Participants.Journal of clinical hypertension (Greenwich, Conn.) · 2025Trial
- Agreement between seven-day and fourteen-day home systolic blood pressure stability scores: A J-HOP study analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- A novel oscillometric method for blood pressure measurement with reduced cuff pressure and measurement time.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Asian expert consensus on high-quality hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Achievement rate of blood pressure control <130/80 mmHg as the core metric of implementation hypertension, based on the new JSH2025 and AHA/ACC2025 guidelines.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Home blood pressure stability score is associated with better cardiovascular prognosis: data from the nationwide prospective J-HOP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Is calculation of a home blood pressure-based stability score a tool to improve risk stratification in clinical practice?Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The association of out-of-office blood pressure time in target range with clinical outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Time in therapeutic range for out-of-office blood pressure in hypertensive disorders of pregnancy: A better risk assessment measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- What are the ideal metrics for assessing the quality of long-term stabilized "perfect" 24-h BP control after renal denervation?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Time in therapeutic range (TTR) for office systolic blood pressure (SBP) is an independent predictor of major cardiovascular events. However, the clinical implications of TTR for home SBP have not yet been investigated. This study determined the association between TTR of home SBP and cardiovascular events in individuals with ≥1 cardiovascular risk factor who were enrolled in The Japan Morning Surge-Home Blood Pressure (J-HOP) study. The therapeutic range for home SBP was defined as home SBP of 100-135 mmHg during the 13-day baseline period of the J-HOP study. Participants were divided into subgroups based on quartiles of TTR for home SBP, and the risk of cardiovascular events was determined in each quartile. During a mean 6.3 years of follow-up in 4070 participants (mean age 65 years), cardiovascular events included stroke in 92, coronary artery disease in 119, heart failure in 41 and aortic dissection in 8. The adjusted hazard ratio (95% confidence interval) for the risk of total cardiovascular events in participants with home SBP TTR in the lowest (100%) versus highest quartile (<15.3%) was 1.74 (1.16-2.61); the corresponding hazard ratio for stroke events was 2.11 (1.06-4.21). A 10% decrease in home SBP TTR was associated with a 4% increase in the risk of total cardiovascular events (p = 0.033) and a 9% increase in the risk of stroke (p = 0.004). The significant association seen between home SBP TTR and the occurrence of cardio- and cerebrovascular events highlights the importance of achieving stable reductions in home SBP and minimizing day-by-day home BP variability.Clinical Trial Registration: University Hospital Medical Information Network Clinical Trials Registry, UMIN000000894 (J-HOP study).
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