ArticleMolecular and cellular endocrinology2023
Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.
Article in Molecular and cellular endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Population Variation in Steroid Hormone-Related Gene Expression and Sexually Dimorphic Communication in the Electric Fish Apteronotus albifrons.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Differential expression of steroid-related genes across electrosensory brain regions in two sexually dimorphic species of electric knifefish.General and comparative endocrinology · 2024Review
- Species variation in steroid hormone-related gene expression contributes to species diversity in sexually dimorphic communication in electric fishes.Hormones and behavior · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hormones and receptors coevolve to generate species diversity in hormone action. We compared the structure and function of androgen receptors (ARs) across fishes, with a focus on ARs in ghost knifefishes (Apteronotidae). Apteronotids, like many other teleosts, have two ARs (ARα and ARβ). ARβ is largely conserved, whereas ARα sequences vary considerably across species. The ARα ligand binding domain (LBD) has evolved under positive selection, and differences in the LBD across apteronotid species are associated with diversity in androgenic regulation of behavior. The Apteronotus leptorhynchus ARα LBD differs substantially from that of the Apteronotus albifrons ARα or the ancestral AR. Structural modeling and transactivation assays demonstrated that A. leptorhynchus ARα cannot bind androgens. We propose a model whereby relative expression of ARα versus ARβ in the brain, coupled with loss of androgen binding by ARα in A. leptorhynchus might explain reversals in androgenic regulation and sex differences in electrocommunication behavior.
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Registered trials
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