Evidence map›Paper›PMID 37713614›Full record

ArticleThe Journal of infectious diseases2024

Risk of Malaria Following Untreated Subpatent Plasmodium falciparum Infections: Results Over 4 Years From a Cohort in a High-Transmission Area in Western Kenya.

Erica E Zeno, Andrew A Obala, Brian Pence, Elizabeth Freedman, Judith N Mangeni, Jessica T Lin, Lucy Abel, Jessie K Edwards, Emily W Gower, Steve M Taylor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Erica E ZenoDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Andrew A ObalaSchool of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya.
Brian PenceDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Elizabeth FreedmanDivision of Infectious Diseases, School of Medicine, Duke University, Durham, North Carolina, USA.
Judith N MangeniSchool of Public Health, College of Health Sciences, Moi University, Eldoret, Kenya.
Jessica T LinDivision of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, USA.
Lucy AbelAcademic Model Providing Access to Healthcare, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Jessie K EdwardsDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Emily W GowerDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Steve M TaylorDivision of Infectious Diseases, School of Medicine, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-2783-0990
University of North Carolina at Chapel Hill · USDuke University · USMoi University · KEAMPATH · KE

Funding

Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
Once bitten: A longitudinal, observational study of successful malaria parasite transmission events between humans and mosquitosR01AI146849 · NIAID · DUKE UNIVERSITY · PI PRUDHOMMEOMEARA, WENDY, TAYLOR, STEVE MYER · 2019 to 2023
$3.0M
Spatial Scales of Plasmodium Falciparum Generations; Implications for EliminationR21AI126024 · NIAID · DUKE UNIVERSITY · PI PRUDHOMMEOMEARA, WENDY · 2017 to 2018
$338k
NIAID NIH HHS R01 AI146849NIAID NIH HHS R21 AI126024NIAID NIH HHS T32 AI070114
6 · The paper itself

Abstract

backgroundPeople with suspected malaria may harbor Plasmodium falciparum undetected by rapid diagnostic test (RDT). The impact of these subpatent infections on the risk of developing clinical malaria is not fully understood.

methodsWe analyzed subpatent P. falciparum infections using a longitudinal cohort in a high-transmission site in Kenya. Weighted Kaplan-Meier models estimated the risk difference (RD) for clinical malaria during the 60 days following a symptomatic subpatent infection. Stratum-specific estimates by age and transmission season assessed modification.

resultsOver 54 months, we observed 1128 symptomatic RDT-negative suspected malaria episodes, of which 400 (35.5%) harbored subpatent P. falciparum. Overall, the 60-day risk of developing clinical malaria was low following all episodes (8.6% [95% confidence interval, 6.7%-10.4%]). In the low-transmission season, the risk of clinical malaria was slightly higher in those with subpatent infection, whereas the opposite was true in the high-transmission season (low-transmission season RD, 2.3% [95% confidence interval, .4%-4.2%]; high-transmission season RD, -4.8% [-9.5% to -.05%]).

conclusionsThe risk of developing clinical malaria among people with undetected subpatent infections is low. A slightly elevated risk in the low-transmission season may merit alternate management, but RDTs identify clinically relevant infections in the high-transmission season.

Indexed as

MalariaMalaria, FalciparumDiagnostic Tests, RoutineHumansKenyaPlasmodium falciparumPrevalenceRiskdiagnosismalariaPlasmodium falciparumrapid diagnostic testsurvival analysis

Identifiers

PMID37713614
PMCPMC11011184
OpenAlexW4386758625

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.