Evidence map›Paper›PMID 37713573›Full record

ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2023

Transdiagnostic risk of mental disorders in offspring of affected parents: a meta-analysis of family high-risk and registry studies.

Rudolf Uher, Barbara Pavlova, Joaquim Radua, Umberto Provenzani, Sara Najafi, Lydia Fortea, Maria Ortuño, Anna Nazarova, Nader Perroud, Lena Palaniyappan and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  11. Evaluating a program to prevent anxiety in children of anxious parents: a randomized controlled trial.Journal of child psychology and psychiatry, and allied disciplines · 2025
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  12. Perceived Need and Social Relatedness Contribute to Change in Selective Prevention for Mental Illness: a Mixed Methods Study.Prevention science : the official journal of the Society for Prevention Research · 2025
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Rudolf UherDalhousie University, Department of Psychiatry, Halifax, NS, Canada.
Barbara PavlovaDalhousie University, Department of Psychiatry, Halifax, NS, Canada.
Joaquim RaduaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain.
Umberto ProvenzaniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Sara NajafiDalhousie University, Department of Psychiatry, Halifax, NS, Canada.
Lydia ForteaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain.
Maria OrtuñoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain.
Anna NazarovaDalhousie University, Department of Psychiatry, Halifax, NS, Canada.
Nader PerroudService of Psychiatric Specialties, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
Lena PalaniyappanDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QB, Canada.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Samuele CorteseSchool of Psychology, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.
Paul D ArnoldMathison Centre for Mental Health Research & Education, University of Calgary, Calgary, AL, Canada.
Jehannine C AustinDepartments of Psychiatry and Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Michael M VanyukovDepartments of Pharmaceutical Sciences, Psychiatry, and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Myrna M WeissmanDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Allan H YoungCentre for Affective Disorders, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Manon H J HillegersDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
Andrea DaneseSocial, Genetic and Developmental Psychiatry Centre and Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Merete NordentoftCopenhagen Research Center for Mental Health, Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark.
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paolo Fusar-PoliDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The offspring of parents with mental disorders are at increased risk for developing mental disorders themselves. The risk to offspring may extend transdiagnostically to disorders other than those present in the parents. The literature on this topic is vast but mixed. To inform targeted prevention and genetic counseling, we performed a comprehensive, PRISMA 2020-compliant meta-analysis. We systematically searched the literature published up to September 2022 to retrieve original family high-risk and registry studies reporting on the risk of mental disorders in offspring of parents with any type of mental disorder. We performed random-effects meta-analyses of the relative risk (risk ratio, RR) and absolute risk (lifetime, up to the age at assessment) of mental disorders, defined according to the ICD or DSM. Cumulative incidence by offspring age was determined using meta-analytic Kaplan-Meier curves. We measured heterogeneity with the I

Indexed as

anxiety disordersbipolar disorderdepressioneating disordersFamilial riskmental disorderspsychosissubstance use disorderstargeted primary preventiontransdiagnostic risk

Identifiers

PMID37713573
PMCPMC10503921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.