ArticleScience advances2023
ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.
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In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Extracellular Vesicle-Derived microRNAs as Fluid Biomarkers in Neurodegenerative Diseases: A Systematic Review.Journal of neurochemistry · 2026Pooled it
- Markers and Enrichment Strategies for Brain-Derived Extracellular Vesicles: Current Evidence, Limitations and Future Directions.Neuromolecular medicine · 2026Review
- Conserved and Tissue-Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig.Journal of extracellular vesicles · 2026Article
- Tissue-Specific Isolation of Hepatocyte Extracellular Vesicles From Human Plasma Enables Tissue-Resolved Proteomic and miRNA Profiling.Journal of extracellular vesicles · 2026Article
- Significance of NAD anabolism profiles in neurological diseases.Metabolic brain disease · 2026Review
- Human iPSC models revealResearch square · 2026Article
- Proteomic comparison of human neural cell-derived extracellular vesicles and parental cells from Alzheimer's disease and cognitively normal individuals.Science China. Life sciences · 2026Article
- The New Spine of Access to the Brain's Secrets: Extracellular Vesicles from Cerebrospinal Fluid Liquid Biopsies in CNS Diseases and Blood-Brain Barrier Research.Molecular neurobiology · 2026Review
- Exosome Biology at the Interface of Neurodegeneration and Therapeutic Innovation.Molecular neurobiology · 2026Review
- Immunoaffinity-Based Protocol to Enrich Nervous System Cell-, Lung Alveolar Cell-, and Hepatocyte-Derived Extracellular Vesicles From Human Plasma.Journal of extracellular biology · 2026Article
- Extracellular vesicle-mediated bidirectional communication between the brain and peripheral organs in Alzheimer's disease: evidence, mechanisms, and translational perspectives.Journal of nanobiotechnology · 2026Review
- Brain-Derived Extracellular Vesicle Subpopulations: from Bulk Measurements to Single-Entity Assays.JACS Au · 2026Review
- Multifactor authentication in extracellular vesicle analysis: methods and approaches to address the heterogeneity problem.Nature methods · 2026Review
- Cargo molecules in plasma neural-derived extracellular vesicles reveal pathological signatures of primary open-angle glaucoma.Journal of translational medicine · 2026Article
- Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model.Nature communications · 2026Article
- Tissue-Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective.Journal of extracellular biology · 2026Review
- Diagnostic potential of cryptic exon-derived peptides in serum extracellular vesicles for sporadic amyotrophic lateral sclerosis.Inflammation and regeneration · 2026Article
- Tetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery.Clinical proteomics · 2026Article
- The recent progression of extracellular vesicles application in osteoporosis.Frontiers in pharmacology · 2026Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Yang YouDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0003-0574-7827
Zhengrong ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-0608-8520
Nadia SultanaDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-8627-101X
Maria EricssonDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4563-3683
Yuka A MartensDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-5194-4269
Min SunNanoview Biosciences, Boston, MA, USA School, Boston, MA, USA.ORCID 0000-0003-4389-9880
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-6751-9374
Seiko IkezuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-9879-730X
Scott A ShafferDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-5264-3257
Tsuneya IkezuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-3979-8596
Boston University · USMayo Clinic in Florida · USUniversity of Massachusetts Chan Medical School · USHarvard University · USUniversity of Massachusetts Boston · US
Funding
Exosome-mediated propagation of pathogenic tau proteinRF1AG054199 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2016 to 2021
$5.0MTargeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s diseaseR01AG054672 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, IKEZU, TSUNEYA · 2017 to 2021
$4.1MMolecular characterization of extracellular vesicles for the spread of misfolded tau proteinR01AG067763 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$3.1MAssessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse modelR01AG072719 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2021 to 2025
$2.7MTherapeutic evaluation of targeting Tau Tubulin kinase-1 in Alzheimer’s diseaseR01AG079859 · NIA · MAYO CLINIC JACKSONVILLE · PI Seiko Ikezu · 2023 to 2026
$2.2MTumor susceptibility gene 101, a new microglial therapy candidate for Alzheimer’s disease to prevent cognitive declineRF1AG082704 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, SEIKO, IKEZU, TSUNEYA · 2023 to 2023
$2.0MTargeting emerging P2RX7 signaling pathways in animal models of Alzheimer's diseaseR01AG066429 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2020 to 2024
$2.0MAPOE and microglia-mediated progression in tau pathology in ADR01AG054199 · NIA · MAYO CLINIC JACKSONVILLE · PI IKEZU, TSUNEYA · 2024 to 2025
$1.4MNIA NIH HHS R01 AG054199NIA NIH HHS R01 AG054672NIA NIH HHS R01 AG066429NIA NIH HHS R01 AG067763NIA NIH HHS R01 AG072719NIA NIH HHS R01 AG079859NIA NIH HHS RF1 AG054199NIA NIH HHS RF1 AG082704
Abstract
Neuron-derived extracellular vesicles (NDEVs) are potential biomarkers of neurological diseases although their reliable molecular target is not well established. Here, we demonstrate that ATPase Na
Indexed as
Alzheimer DiseaseExtracellular VesiclesBrainHumansNeural Cell Adhesion MoleculesNeuronsProteomicsSodium-Potassium-Exchanging ATPaseATP1A3 protein, humanNeural Cell Adhesion MoleculesSodium-Potassium-Exchanging ATPase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.