Evidence map›Paper›PMID 37713301›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Protease-armed, Pathogenic Extracellular Vesicles Link Smoking and Chronic Obstructive Pulmonary Disease.

Matthew C Madison, Camilla Margaroli, Kristopher R Genschmer, Derek W Russell, James M Wells, Ezgi Sari, Yixel M Soto-Vazquez, Yuan-Yuan Guo, Kyle T Mincham, Robert J Snelgrove and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026
    Review
  3. Cellular plasticity and regenerative mechanisms in the lung.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Matthew C MadisonDepartment of Clinical and Diagnostic Science.ORCID 0000-0001-8143-7471
Camilla MargaroliDepartment of Pathology.ORCID 0000-0003-3952-0778
Kristopher R GenschmerDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.
Derek W RussellDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.
James M WellsDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.ORCID 0000-0001-9612-5454
Ezgi SariDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.
Yixel M Soto-VazquezDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.
Yuan-Yuan GuoBirmingham VA Medical Center, Birmingham, Alabama; and.
Kyle T MinchamNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Robert J SnelgroveNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Amit GaggarDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.
James E BlalockDivision of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine.
University of Alabama at Birmingham · USPulmonary and Allergy Associates · USImperial College London · GBBirmingham VA Medical Center · USCentre de Recherche en Sciences et Technologies de l'Information et de la Communication · FR

Funding

Mentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2M
A Novel Exosomal Inflammatory PathwayR35HL135710 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2017 to 2023
$6.8M
Pathogenic Exosomes in COPDR35HL166433 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI J Edwin Blalock · 2023 to 2026
$4.1M
A Novel Proteolytic System of Pulmonary InflammationR01HL102371 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2021
$3.3M
Matrikines and COPD-PHR01HL148215 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2019 to 2023
$2.4M
Role of heme and PGP matrikines in lung inflammationR01HL153113 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT, PATEL, RAKESH P. · 2020 to 2023
$2.2M
A Pathogenic Smoke Associated Neutrophilic Exosomal Pathway.R01HL162705 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kristopher R. Genschmer · 2022 to 2026
$1.9M
Activated Neutrophilic Exosome as Biomarker and Therapeutic Target in COPDK08HL148514 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RUSSELL, DEREK · 2020 to 2024
$824k
CSRD VA I01 CX001969NHLBI NIH HHS K08 HL148514NHLBI NIH HHS K08HL148514NHLBI NIH HHS R01 HL102371NHLBI NIH HHS R01HL102371NHLBI NIH HHS R01 HL148215NHLBI NIH HHS R01 HL153113NHLBI NIH HHS R01HL153113NHLBI NIH HHS R01 HL162705NHLBI NIH HHS R35 HL135710NHLBI NIH HHS R35HL135710NHLBI NIH HHS R35 HL166433NHLBI NIH HHS R35HL166433NIGMS NIH HHS K12 GM088010Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

EmphysemaPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAnimalsDisease Models, AnimalHumansLungMatrix Metalloproteinase 12MicePancreatic ElastasePeptide HydrolasesSmokingMatrix Metalloproteinase 12Pancreatic ElastasePeptide HydrolasesCOPDEVsmacrophageneutrophilprotease

Identifiers

PMID37713301
PMCPMC10867940
OpenAlexW4386768791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.