ArticleGeroScience2024
Regional differences in the link between water exchange rate across the blood-brain barrier and cognitive performance in normal aging.
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Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Repeatability of diffusion-weighted arterial spin labeling MRI for mapping blood-brain barrier water exchange rate at different postlabel delays.Magnetic resonance in medicine · 2026Article
- Cerebral Blood Flow and Blood-Brain Barrier Water Exchange in Major Depressive Disorder: Evidence from Diffusion-Prepared Arterial Spin Labelling MRI.Brain sciences · 2025Article
- Intracerebral Hemorrhage in Aging: Pathophysiology, Clinical Challenges, and Future Directions.Life (Basel, Switzerland) · 2025Review
- The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation-A Narrative Review.Nutrients · 2025Review
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- Review of the Role of TRAF7 in Brain Endothelial Integrity and Cerebrovascular Aging.Life (Basel, Switzerland) · 2025Review
- Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults.GeroScience · 2025Article
- Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study.Neurobiology of aging · 2025Article
- Article
- Blood-brain barrier disruption: a culprit of cognitive decline?Fluids and barriers of the CNS · 2024Review
- Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions.bioRxiv : the preprint server for biology · 2024Article
- MRI free water mediates the association between water exchange rate across the blood brain barrier and executive function among older adults.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Association of pulsatility index with total burden of cerebral small vessel disease and cognitive impairment.Brain and behavior · 2024Article
- Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study.NeuroImmune pharmacology and therapeutics · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Valentinos ZachariouDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA. vzachari@uky.edu.ORCID 0000-0001-8518-5638
Colleen PappasDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA.
Christopher E BauerDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Peiying LiuDepartment of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Danny J J WangLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brian T GoldDepartment of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA.
University of Kentucky · USUniversity of Southern California · USJohns Hopkins University · USUniversity of Maryland, Baltimore · US
Funding
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Karen J. Bandeen-Roche · 2020 to 2026
$29.3MUniversity of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI GREGORY A JICHA · 2021 to 2026
$23.5MUniversity of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, VAN ELDIK, LINDA J · 2006 to 2020
$23.3MTRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9MValidation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationU01NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2023 to 2025
$3.9MIdentifying Associations between Brain Iron, Neurocognitive Networks and Protective FactorsR01AG068055 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY · 2021 to 2025
$2.8MAn integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7MValidation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersUF1NS100588 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., LU, HANZHANG · 2021 to 2021
$2.6MContributions of Alzheimer's Pathology and Cerebrovascular Factors to Cognitive AgingR01AG055449 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY · 2017 to 2021
$2.3MReduced BBB Water Exchange as a Preclinical Biomarker of Small Vessel DiseaseRF1NS122028 · NINDS · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, WANG, DANNY JJ · 2022 to 2022
$2.0MBBB Permeability Imaging in CADASILR01NS114382 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, DANNY JJ · 2020 to 2024
$1.2MEssential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research ScannerS10OD023573 · OD · UNIVERSITY OF KENTUCKY · PI SMITH, CHARLES DENNIS · 2017 to 2017
$813kNIA NIH HHS P30 AG028383NIA NIH HHS P30 AG028383 - 15S1NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG055449NIA NIH HHS R01 AG068055NIBIB NIH HHS P41 EB031771NIGMS NIH HHS S10 OD023573NIH HHS S10 OD023573NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS114382NINDS NIH HHS RF1 NS122028NINDS NIH HHS U01 NS100614NINDS NIH HHS UF1 NS100588
Abstract
The blood-brain barrier (BBB) undergoes functional changes with aging which may contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI technique can measure the rate of water exchange across the BBB (k
Indexed as
Blood-Brain BarrierWhite MatterAgedAged, 80 and overAgingCognitionHumansWaterWaterBBB water exchange rateBiological mechanismsCognitive performanceNormal aging
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.