ArticleCritical care science
Biomarkers of neuropsychiatric dysfunction in intensive care unit survivors: a prospective cohort study.
Article in Critical care science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of delirium with post-traumatic stress disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Inflammatory Biomarkers and Post-Intensive Care Syndrome: A Prospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Association of systemic inflammation and long-term dysfunction in COVID-19 patients: A prospective cohort.Psychoneuroendocrinology · 2025Article
- To: Biomarkers of neuropsychiatric dysfunction in intensive care unit survivors: a prospective cohort study.Critical care science · 2024Article
- From critical care units to postacute care facilities: the sooner, the better?Critical care science · 2024Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess factors associated with long-term neuropsychiatric outcomes, including biomarkers measured after discharge from the intensive care unit.
methodsA prospective cohort study was performed with 65 intensive care unit survivors. The cognitive evaluation was performed through the Mini-Mental State Examination, the symptoms of anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale, and posttraumatic stress disorder was evaluated using the Impact of Event Scale-6. Plasma levels of amyloid-beta (1-42) [Aβ (1-42)], Aβ (1-40), interleukin (IL)-10, IL-6, IL-33, IL-4, IL-5, tumor necrosis factor alpha, C-reactive protein, and brain-derived neurotrophic factor were measured at intensive care unit discharge.
resultsOf the variables associated with intensive care, only delirium was independently related to the occurrence of long-term cognitive impairment. In addition, higher levels of IL-10 and IL-6 were associated with cognitive dysfunction. Only IL-6 was independently associated with depression. Mechanical ventilation, IL-33 levels, and C-reactive protein levels were independently associated with anxiety. No variables were independently associated with posttraumatic stress disorder.
conclusionCognitive dysfunction, as well as symptoms of depression, anxiety, and posttraumatic stress disorder, are present in patients who survive a critical illness, and some of these outcomes are associated with the levels of inflammatory biomarkers measured at discharge from the intensive care unit.
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