Evidence map›Paper›PMID 37712753›Full record

ArticleInternational journal of methods in psychiatric research2023

Developmentally specified characterization of the irritability spectrum at early school age: Implications for pragmatic mental health screening.

Emily Hirsch, Tasmia Alam, Nathan Kirk, Katherine B Bevans, Margaret Briggs-Gowan, Lauren S Wakschlag, Jillian L Wiggins, Amy K Roy

Abstract read
In one paragraph

Article in International journal of methods in psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026
    Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emily HirschDepartment of Psychology, Fordham University, Bronx, New York, USA.ORCID 0000-0001-6891-3226
Tasmia AlamDepartment of Psychology, San Diego State University, San Diego, California, USA.ORCID 0009-0003-9605-8871
Nathan KirkDepartment of Psychology, San Diego State University, San Diego, California, USA.ORCID 0000-0002-3645-9994
Katherine B BevansJanssen Global Services LLC, Horsham, Pennsylvania, USA.
Margaret Briggs-GowanDepartment of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut, USA.
Lauren S WakschlagDepartment of Medical Social Sciences, Feinberg School of Medicine and Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, Illinois, USA.
Jillian L WigginsDepartment of Psychology, San Diego State University, San Diego, California, USA.ORCID 0000-0002-4931-6589
Amy K RoyDepartment of Psychology, Fordham University, Bronx, New York, USA.

Funding

Dimensions of Early Temper Loss and Low Concern: Clinical Utility and MechanismsU01MH082830 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2014 to 2018
$3.9M
Developmental Characterization of Preschool Disruptive BehaviorR01MH082830 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2009 to 2013
$3.7M
Early Traumatic Stress Exposure: Neurodevelopmental Mechanisms of Clinical RiskU01MH090301 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRIGGS-GOWAN, MARGARET J · 2012 to 2014
$2.4M
NIH HHS 2U01MH082830NIH HHS R01MH082830NIMH NIH HHS R01 MH082830NIMH NIH HHS U01 MH082830NIMH NIH HHS U01 MH090301
6 · The paper itself

Abstract

objectivesDevelopmentally specified measures that identify clinically salient irritability are needed for early school-age youth to meaningfully capture this transdiagnostic risk factor for psychopathology. Thus, the current study modeled the normal:abnormal irritability spectrum and generated a clinically optimized screening tool for this population.

methodsThe irritability spectrum was modeled via the youth version of the Multidimensional Assessment Profile Scales-Temper Loss Scale (MAPS-TL-Youth) in children (n = 474; 6.0-8.9 years) using item response theory (IRT). Both cross-cutting core irritability items from the early childhood version and new developmentally specific items were included. Items uniquely associated with impairment were identified and used to derive a brief, clinically optimized irritability screener. Longitudinal data were then utilized to test the predictive utility of this clinically optimized screener in preadolescence (n = 348; 8.0-12.9 years).

resultsMost children exhibit irritability regularly, but daily occurrence was rare. Of the top 10 most severe items from the IRT analyses, 9 were from the developmentally specific items added for the MAPS-TL Youth version. Two items associated with concurrent impairment were identified for the clinically optimized irritability screener ("Become frustrated easily" and "Act irritable"). The MAPS-TL-Youth clinically optimized screener demonstrated good sensitivity (69%) and specificity (84%) in relation to concurrent DSM 5 irritability-related diagnoses. Youth with elevated scores on the screener at early school age (ESA) had more than 7x greater odds of irritability-related psychopathology at pre-adolescence.

conclusionsThe MAPS-TL-Youth characterized the developmental spectrum of irritability at ESA and a clinically optimized screener showed promise at predicting psychopathology risk. Rigorous testing of clinical applications is a critical next step.

Indexed as

Irritable MoodMental HealthAdolescentChildChild, PreschoolHumansassessmentdevelopmental psychopathologypediatric irritability

Identifiers

PMID37712753
PMCPMC10654842

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.