Evidence map›Paper›PMID 37712728›Full record

ArticleCritical care science2023

Maximal expiratory pressure compared with maximal expiratory pressure during induced cough as a predictor of extubation failure.

Melina Carrera, Jose García Urrutia, Cesar Bueno Ardariz, Maria Luz Porra, Claudio Gamarra, Ladislao Pablo Diaz Ballve

Registry-linked trialAbstract read
In one paragraph

Article in Critical care science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04356625 (Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure in Intensive Care Unit Patients on Mechanical Ventilation Ready to Extubate. A Single-arm Open Clinical Trial.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04356625 nacompletednot on this map

Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure in Intensive Care Unit Patients on Mechanical Ventilation Ready to Extubate. A Single-arm Open Clinical Trial.

TypeinterventionalSponsorHospital Nacional Profesor Alejandro PosadasRan2018 to 2019Enrolled80ConditionsAirway ExtubationArmsMEPic
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Ultrasound assessment of abdominal respiratory muscles during ventilator weaning: A scoping review.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melina CarreraHospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.ORCID 0000-0001-9684-6278
Jose García UrrutiaHospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.ORCID 0000-0001-6658-4019
Cesar Bueno ArdarizHospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.ORCID 0000-0001-8510-6274
Maria Luz PorraHospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.ORCID 0000-0001-6624-1796
Claudio GamarraHospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.ORCID 0000-0002-4774-6403
Ladislao Pablo Diaz BallveHospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.ORCID 0000-0001-9911-7468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the diagnostic performance of maximal expiratory pressure with maximal expiratory pressure during induced cough for predicting extubation failure within 72 hours in patients who completed a spontaneous breathing trial (SBT).

methodsThe study was conducted between October 2018 and September 2019. All patients aged over 18 years admitted to the intensive care unit who required invasive mechanical ventilation for over 48 hours and successfully completed a spontaneous breathing trial were included. The maximal expiratory pressure was assessed with a unidirectional valve for 40 seconds, and verbal encouragement was given. The maximal expiratory pressure during induced cough was measured with slow instillation of 2mL of a 0.9% saline solution. The primary outcome variable was extubation failure.

resultsEighty patients were included, of which 43 (54%) were male. Twenty-two patients [27.5% (95%CI 18.9 - 38.1)] failed extubation within 72 hours. Differences were observed in the maximal expiratory pressure during induced cough between the group who failed extubation, with a median of 0cmH2O (P25-75: 0 - 90), and the group without extubation failure, with a median of 120cmH2O (P25-75: 73 - 120); p < 0.001.

conclusionIn patients who completed a spontaneous breathing trial, the maximal expiratory pressure during induced cough had a higher diagnostic performance for predicting extubation failure within 72 hours.Clinicaltrials.gov Registry: NCT04356625.

Indexed as

Airway ExtubationMaximal Respiratory PressuresAdultCathetersCoughFemaleHumansMaleMiddle AgedRespiration, ArtificialSaline SolutionSaline SolutionAirway extubationCoughDiagnostic techniques and proceduresMaximal respiratory pressures

Identifiers

PMID37712728
PMCPMC10275301

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.