ArticleCritical care science2023
High
Article in Critical care science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05068713 (High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation), which is not on this map. Not yet cited in PubMed.
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High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explain the rationale and protocol of the methods and analyses to be used in the LIVER-PAM randomized clinical trial, which seeks to understand whether a higher mean arterial pressure is capable of reducing the incidence of renal dysfunction postoperatively after liver transplantation.
methodsLIVER-PAM is an open-label, randomized, controlled, singlecenter clinical trial. Patients randomized to the intervention group will have a mean arterial pressure of 85 - 90mmHg in the initial 24 hours of postoperative management, while patients in the control group will have a mean arterial pressure of 65 - 70mmHg in the same period. A sample of 174 patients will be required to demonstrate a 20% reduction in the absolute incidence of renal dysfunction, with a power of 80% and an alpha of 0.05.
conclusionIf a 20% reduction in the absolute incidence of renal dysfunction in the postoperative period of liver transplantation is achieved with higher target mean arterial pressure in the first 24 hours, this would represent an inexpensive and simple therapy for improving current outcomes in the management of liver transplant patients.ClinicalTrials.gov Registry: NCT05068713.
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