Evidence map›Paper›PMID 37712594›Full record

ArticleACS infectious diseases2023

Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in

John M Bennett, Kurt E Ward, Ryan K Muir, Stephanie Kabeche, Euna Yoo, Tomas Yeo, Grace Lam, Hao Zhang, Jehad Almaliti, Gabriel Berger and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Ubiquitin-proteasome system inFrontiers in medicine · 2024
    Pooled it
  2. Article
  3. Profiling 26S Proteasome Activity ofInternational journal of molecular sciences · 2026
    Article
  4. A recombinant expression system for thebioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates.Protein science : a publication of the Protein Society · 2025
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

John M BennettDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Kurt E WardDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, United States.ORCID 0000-0002-3614-436X
Ryan K MuirDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.
Stephanie KabecheDepartment of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, United States.
Euna YooDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.ORCID 0000-0001-5982-1979
Tomas YeoDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, United States.
Grace LamDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94304, United States.
Hao ZhangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10065, United States.ORCID 0000-0002-1187-5844
Jehad AlmalitiSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.
Gabriel BergerDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.
Franco F FaucherDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Gang LinDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10065, United States.ORCID 0000-0003-4797-7073
William H GerwickScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92037, United States.
Ellen YehDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.
David A FidockDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, United States.
Matthew BogyoDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.ORCID 0000-0003-3753-4412
Stanford University · USColumbia University Irving Medical Center · USCornell University · USScripps Institution of Oceanography · USNational Institutes of Health · USUniversity of California San Diego · US

Funding

Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarialsR01AI143714 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gang Lin · 2019 to 2026
$6.1M
Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Harnessing the Unique Biogenesis of the Apicomplexan plastid organelle forAntimalarial TargetsR01AI141366 · NIAID · STANFORD UNIVERSITY · PI YEH, ELLEN · 2019 to 2023
$2.9M
Parasite-specific proteasome inhibitors to combat multi-drug resistant malariaR21AI127581 · NIAID · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2017 to 2018
$447k
NIAID NIH HHS R01 AI109023NIAID NIH HHS R01 AI141366NIAID NIH HHS R01 AI143714NIAID NIH HHS R21 AI127581
6 · The paper itself

Abstract

The

Indexed as

AntimalarialsDrug ResistancePlasmodium falciparumProteasome Endopeptidase ComplexProteasome InhibitorsHumansMacrocyclic CompoundsMalaria, FalciparumSulfonesAntimalarialsMacrocyclic CompoundsProteasome Endopeptidase ComplexProteasome InhibitorsSulfonesantimicrobial resistancecyclic peptidesPlasmodium falciparum;

Identifiers

PMID37712594
PMCPMC10591878
OpenAlexW4386757841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.