Evidence map›Paper›PMID 37712519›Full record

ArticleEnvironmental toxicology and chemistry2023

Increased Endocrine Activity of Xenobiotic Chemicals as Mediated by Metabolic Activation.

Richard C Kolanczyk, Jeffrey S Denny, Barbara R Sheedy, Victoria V Olson, Jose A Serrano, Mark A Tapper

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental toxicology and chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Richard C KolanczykGreat Lakes Toxicology and Ecology Division, Office of Research and Development, Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Duluth, Minnesota.
Jeffrey S DennyGreat Lakes Toxicology and Ecology Division, Office of Research and Development, Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Duluth, Minnesota.
Barbara R SheedyGreat Lakes Toxicology and Ecology Division, Office of Research and Development, Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Duluth, Minnesota.
Victoria V OlsonDepartment of Biology, The College of Saint Scholastica, Duluth, Minnesota, USA.
Jose A SerranoGreat Lakes Toxicology and Ecology Division, Office of Research and Development, Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Duluth, Minnesota.
Mark A TapperGreat Lakes Toxicology and Ecology Division, Office of Research and Development, Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Duluth, Minnesota.ORCID 0000-0002-7994-616X
Environmental Protection Agency · USCollege of St. Scholastica · US

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

The US Environmental Protection Agency (USEPA) is faced with long lists of chemicals that require hazard assessment. The present study is part of a larger effort to develop in vitro assays and quantitative structure-activity relationships applicable to untested chemicals on USEPA inventories through study of estrogen receptor (ER) binding and estrogen-mediated gene expression in fish. The present effort investigates metabolic activation of chemicals resulting in increased estrogenicity. Phenolphthalin (PLIN) was shown not to bind rainbow trout (Oncorhynchus mykiss) ER (rtER) in a competitive binding assay, but vitellogenin (Vtg) expression was induced in trout liver slices exposed to 10

Indexed as

Oncorhynchus mykissXenobioticsActivation, MetabolicAnimalsEstradiolHumansRNA, MessengerVitellogeninsEstradiolRNA, MessengerVitellogeninsXenobiotics4,4′-MethylenedianilineBiotransformationEstrogen receptorMetabolismPhenolphthaleinPhenolphthalinRainbow trout

Identifiers

PMID37712519
PMCPMC12068233
OpenAlexW4386758088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.