Evidence map›Paper›PMID 37712283›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[A transcriptomic study of osteoporosis induced by ketogenic diet in mice].

X Wu, Y Fan, Y Ye, P Li, Q Zhu, Z Chen, B Li, W Wang, L Zheng

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

X WuClinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Y FanClinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Y YeDepartment of Pharmacy, Panyu Hospital of Traditional Chinese Medicine, Guangzhou 511400, China.
P LiDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Q ZhuDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z ChenDepartment of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
B LiClinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
W WangClinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
L ZhengClinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the molecular mechanism of osteoporosis caused by ketogenic diet (KD) using transcriptomic analysis.

methodsSixteen 8-week-old female C57BL/6J mice were divided into KD group and sham group for feeding with KD and normal diet for 3 months, respectively. Body weight, blood glucose and blood ketone levels of the mice were measured every two weeks. Microstructure of the cancellous bone in the distal femur was observed with Micro-CT. Total RNA was extracted from bone marrow cells for transcriptomic analysis and bioinformatics analysis. RT-qPCR was used to verify the expression levels of the genes with significant differential expression between the groups.

resultsKD obviously weakened the microstructure of the cancellous bone in mice. Compared with those in the sham group, the mice in KD group showed 165 differentially expressed genes (94 up-regulated and 71 down-regulated ones), including

conclusionThe differentially expressed genes and enriched pathways identified in the mouse models provide new clues for studying the molecular mechanism and prevention of KD-induced osteoporosis.

Indexed as

Diet, KetogenicOsteoporosisAnimalsFemaleGene Expression ProfilingMiceMice, Inbred C57BLTranscriptomeketogenic dietosteoporosistranscriptomics

Identifiers

PMID37712283
PMCPMC10505562

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