Evidence map›Paper›PMID 37712268›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer].

Z Xie, L Liu, J Fang, X Zhong, J Lin, F Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Z XieCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China.
L LiuHexian Memorial Hospital Affiliated to Southern Medical University, Guangzhou 511400, China.
J FangHexian Memorial Hospital Affiliated to Southern Medical University, Guangzhou 511400, China.
X ZhongCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China.
J LinCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China.
F ChenCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of Rho GTPase-activating protein 21 (ARHGAP21) in regulating the migration and metastasis of non-small cell lung cancer (NSCLC) cells.

methodsTCGA, CPTAC database were used to analyze the correlation of ARHGAP21 expression level in NSCLC and the patients' prognosis. The expression of ARHGAP21 in clinical specimens of NSCLC tissues was examined using Western blotting and immunohistochemistry. The effect of ARHGAP21 knockdown on migration ability of lung cancer cell lines was examined using Transwell assay and wound healing assay. A nude mouse model with injection of lung cancer H1299 cells

resultsA low ARHGAP21 expression was associated with poor prognosis of patients with NSCLC (

conclusionARHGAP21 downregulation can significantly promote the migration and metastatic ability of NSCLC possibly as a result of WNT signaling pathway activation, which reduces the ubiquitination of β-catenin by affecting the expressions of APC, GSK3β, and Axin.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAnimalsAxin Proteinbeta CateninCadherinsEpithelial-Mesenchymal TransitionGlycogen Synthase Kinase 3 betaGTPase-Activating ProteinsMiceMice, NudeTranscription FactorsWnt Signaling PathwayARHGAP20 protein, humanAxin Proteinbeta CateninCadherinsGlycogen Synthase Kinase 3 betaGTPase-Activating ProteinsTranscription Factorsepithelial-mesenchymal transitionnon-small cell lung cancerRho GTPase-activating protein 21WNT signaling pathway

Identifiers

PMID37712268
PMCPMC10505574

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