Evidence map›Paper›PMID 37712267›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

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X Guo, L Chen, Q Lü, R DU, Q Luo, Y Zhang, H Bian, L Han

Abstract readEnglish Abstract
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

X GuoZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.
L ChenZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.
Q LüDepartment of Chinese Medicine, Nanyang Medical College, Nanyang 473061, China.
R DUZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.
Q LuoZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.
Y ZhangZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.
H BianZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.
L HanZhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology, Nanyang 473061, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the inhibitory effect of

methodsSixty Wistar rats were randomized into 4 groups for daily gavage of saline or 4, 8, or 16 g/kg GFC suspension for 5 days to prepare blank and low-, medium- and high-dose GFC-medicated sera. Cisplatinresistant ovarian cancer SKOV3/DDP cells were treated with these sera with nuclear factor-κB (NF-κB) inhibitor SN50 as the positive control, and the changes in migration ability and apoptosis of the cells were examined using scratch assay and flow cytometry, respectively; the changes in the mRNA and protein expressions of CDH1, CDH2, caspase 3 and NF- κB were detected using RT-qPCR and Western blotting. ATAC-seq was used to analyze the changes in expressions of CDH1, CDH2, caspase 3 and NF-κB genes in the open chromatin.

resultsTreatment with GFC-medicated sera dose-dependently inhibited the migration (

conclusionGFC- medicated sera inhibits the migration ability of SKOV3/DDP cells possibly by promoting cell apoptosis and caspase 3 and CDH1 expressions, inhibiting CDH2 and NF-κB expressions, and regulating the expressions of NF-κB, CDH2 and CDH1 in the open chromatin.

Indexed as

Ovarian NeoplasmsWolfiporiaAnimalsApoptosisCaspase 3ChromatinFemaleHumansI-kappa B ProteinsNF-kappa BRatsRats, WistarSignal TransductionCaspase 3ChromatinI-kappa B ProteinsNF-kappa Bcaspase 3E-cadherinepithelial-mesenchymal transitionGuizhi Fuling CapsuleN-cadherinnuclear factor- kappa Bovarian cancer

Identifiers

PMID37712267
PMCPMC10505568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.