Evidence map›Paper›PMID 37712262›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy].

M Zhang, Y Zhang, M Niu, Y Zhu, S Tong, X Kou

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M ZhangCollege of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.
Y ZhangCollege of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.
M NiuCollege of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.
Y ZhuCollege of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.
S TongCollege of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.
X KouCollege of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of 8-week dihydromyricetin (DHM) treatment on motor ability of mice with MPTP/probenecid-induced Parkinson's disease (PD) and explore the molecular mechanism.

methodsSixty C57BL/6 mice were randomized into the control group, PD model group, PD+DHM group and PD+NEC-1 group (

resultsThe PD mouse models showed significantly reduced TH-positive cells and TH protein expression (

conclusionDHM can improve motor function of PD mice probably by activating autophagy to inhibit pyroptosis and necroptosis and reduce neuroinflammation.

Indexed as

Interleukin-6Parkinson DiseaseAnimalsAutophagyFlavonolsMiceMice, Inbred C57BLNecroptosisNeuroinflammatory DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinProbenecidPyroptosisTumor Necrosis Factor-alphadihydromyricetinFlavonolsInterleukin-6NLR Family, Pyrin Domain-Containing 3 ProteinProbenecidTumor Necrosis Factor-alphaautophagydihydromyricetinMPTPnecroptosisneuroinflammationprobenecidpyroptosis

Identifiers

PMID37712262
PMCPMC10505583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.