Evidence map›Paper›PMID 37712070›Full record

ArticleCell & gene therapy insights2022

IsoTag

Jennifer Haley, J B Jones, Sophia Petraki, Melissa Callander, Shaleen Shrestha, Emily Springfield, Laura Adamson, Ashutosh Chilkoti, Michael J Dzuricky, Kelli M Luginbuhl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & gene therapy insights, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer HaleyIsolere Bio, Inc., 4021 Stirrup Creek Dr, Ste 210, Durham, NC 27703.
J B JonesIsolere Bio, Inc., 4021 Stirrup Creek Dr, Ste 210, Durham, NC 27703.
Sophia PetrakiCapsida Biotherapeutics, 1300 Rancho Conejo Blvd., Thousand Oaks, CA 91320.
Melissa CallanderIsolere Bio, Inc., 4021 Stirrup Creek Dr, Ste 210, Durham, NC 27703.
Shaleen ShresthaIsolere Bio, Inc., 4021 Stirrup Creek Dr, Ste 210, Durham, NC 27703.
Emily SpringfieldCapsida Biotherapeutics, 1300 Rancho Conejo Blvd., Thousand Oaks, CA 91320.
Laura AdamsonCapsida Biotherapeutics, 1300 Rancho Conejo Blvd., Thousand Oaks, CA 91320.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Michael J DzurickyIsolere Bio, Inc., 4021 Stirrup Creek Dr, Ste 210, Durham, NC 27703.
Kelli M LuginbuhlIsolere Bio, Inc., 4021 Stirrup Creek Dr, Ste 210, Durham, NC 27703.

Funding

ViraTag: A Scalable Purification Technology for Adeno-Associated Virus Gene Therapy VectorsR44GM139503 · NIGMS · ISOLERE BIO, INC. · PI LUGINBUHL, KELLI MICHELLE · 2021 to 2022
$961k
NIGMS NIH HHS R44 GM139503
6 · The paper itself

Abstract

Demand for gene therapies capable of treating previously inaccessible targets has risen precipitously in the past decade. Adeno-associated viruses (AAVs) are the preferred vector for gene delivery because of their favorable safety profile and tissue tropism, but they have significant manufacturing challenges, with end-to-end yields as low as 10-30%. To combat these low yields, we developed IsoTag

Identifiers

PMID37712070
PMCPMC10501529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.