ReviewFrontiers in cellular and infection microbiology2023
Bacterial biofilms in the human body: prevalence and impacts on health and disease.
Review in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip.Antimicrobial agents and chemotherapy · 2024Trial
- Bacterial Biofilm and Titanium Implants: Mechanisms, Clinical Problems, and Surface Modification Strategies.Materials (Basel, Switzerland) · 2026Review
- Wrinkle-like structures emerge from matrix complementarity and mechanical discontinuity in heterogenous biofilms.NPJ biofilms and microbiomes · 2026Article
- Sesquiterpenoids fromMolecules (Basel, Switzerland) · 2026Article
- Use of Micro/Nanorobots In Vivo for the Eradication of Bacterial Biofilm: A Review of Challenges and Strategies.Nanomaterials (Basel, Switzerland) · 2026Review
- Modeling chronic infection withInfection and immunity · 2026Article
- Tackling Biofilm-Forming Pathogens: A Challenge to Overcome in the Fight Against Infectious Diseases.Pathogens (Basel, Switzerland) · 2026Review
- Host-Pathogen Crosstalk in Pediatric Peritoneal Dialysis-Associated Peritonitis: Molecular Mechanisms Driving Peritoneal Membrane Remodeling.International journal of molecular sciences · 2026Review
- Nanomedicine Strategies Against Biofilm-Associated Infections: Advances, Challenges, and Translational Barriers.MicrobiologyOpen · 2026Review
- Bacterial biofilm conundrum: insight into the frontiers of antibiotic resistance and state-of-the-art anti-biofilm interventions.Frontiers in cellular and infection microbiology · 2026Review
- Bacterial diversity in the jelly of shark Ampullae of Lorenzini: a holobiont perspective.PeerJ · 2026Article
- Quinazoline-Derivatives of Imino-1,2,3-Dithiazoles Promote Biofilm Dispersion ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Activity of lactic acid bacteria against biofilms formed by Staphylococcus aureus strains involved in acute mastitis.Scientific reports · 2025Article
- Biosurfactants as novel antibiofilm agents: mechanisms, biomedical applications, and applications in biofilm-associated infections.Archives of microbiology · 2025Review
- Hijacking anaerobic metabolism to restore antibiotic efficacy inApplied and environmental microbiology · 2025Article
- Molecular analyses of community-acquired Staphylococcus epidermidis biofilm development, molecular virulence, and pattern of antibiotic resistance.Molecular biology reports · 2025Article
- Genetic Characterization ofToxins · 2025Article
- Functional flexibility of a type III polyketide synthase iniScience · 2025Article
- Can Salivary Biomarkers Serve as Diagnostic and Prognostic Tools for Early Detection in Patients with Colorectal Cancer? A Systematic Review.Current issues in molecular biology · 2025Review
- Biofilm formation by the host microbiota: a protective shield against immunity and its implication in cancer.Molecular cancer · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial biofilms can be found in most environments on our planet, and the human body is no exception. Consisting of microbial cells encased in a matrix of extracellular polymers, biofilms enable bacteria to sequester themselves in favorable niches, while also increasing their ability to resist numerous stresses and survive under hostile circumstances. In recent decades, biofilms have increasingly been recognized as a major contributor to the pathogenesis of chronic infections. However, biofilms also occur in or on certain tissues in healthy individuals, and their constituent species are not restricted to canonical pathogens. In this review, we discuss the evidence for where, when, and what types of biofilms occur in the human body, as well as the diverse ways in which they can impact host health under homeostatic and dysbiotic states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.