ArticleDystonia (Lausanne, Switzerland)2023
Transient dystonia correlates with parkinsonism after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine in nonhuman primates.
S A Norris, L Tian, E L Williams, J S Perlmutter
Abstract read
In one paragraphArticle in Dystonia (Lausanne, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
4 authors.
S A NorrisDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
L TianDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
E L WilliamsDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
J S PerlmutterDepartment of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
Funding
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2MMECHANISMS OF DEEP BRAIN STIMULATIONR01NS041509 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2015
$6.8MVALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONSR01NS058714 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2008 to 2016
$4.4MNeuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3MNeuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1MThe Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0MCARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISMR01NS050425 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2005 to 2009
$2.6MPATHOPHYSIOLOGY OF DYSTONIA AND PARKINSONISMR01NS039821 · NINDS · WASHINGTON UNIVERSITY · PI MINK, JONATHAN W. · 2000 to 2011
$2.4MInvestigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3MRESCUE FROM NIGROSTRIATAL INJURYR01NS039913 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2003
$1.2MNINDS NIH HHS R01 NS039821NINDS NIH HHS R01 NS039913NINDS NIH HHS R01 NS041509NINDS NIH HHS R01 NS050425NINDS NIH HHS R01 NS058714NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS124789NINDS NIH HHS RF1 NS075321
6 · The paper itselfAbstract
Unilateral internal carotid artery 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion in non-human primates produces transient contralateral hemi-dystonia followed by stable contralateral hemi-parkinsonism; the relationship between dystonia and parkinsonism remains unclear. We hypothesized that transient dystonia severity following MPTP correlates with parkinsonism severity. In male Macaca nemestrina (
Indexed as
monkeyMPTPplasticitystriatumsubstantia nigra
Identifiers
PMID37711667
PMCPMC10501383
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