Evidence map›Paper›PMID 37711505›Full record

ArticleOrthopaedic journal of sports medicine2023

Safety and Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells for Chronic Patellar Tendinopathy (With Gap >3 mm) in Patients: 12-Month Follow-up Results of a Phase 1/2 Clinical Trial.

Robert Soler, Gil Rodas, Joan Rius-Tarruella, Xavier Alomar, Ramon Balius, Ángel Ruíz-Cotorro, Lorenzo Masci, Nicola Maffulli, Lluís Orozco

Abstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert SolerInstitut de Teràpia Regenerativa Tissular (ITRT), Centro Médico Teknon Hospital, Barcelona, Spain.
Gil RodasMedical Department FC Barcelona, Barcelona, Spain.
Joan Rius-TarruellaInstitut de Teràpia Regenerativa Tissular (ITRT), Centro Médico Teknon Hospital, Barcelona, Spain.
Xavier AlomarDiagnóstico por la Imagen, Clínica Creu Blanca, Barcelona, Spain.
Ramon BaliusConsell Català de l'Esport, Generalitat de Catalunya, Barcelona, Spain.
Ángel Ruíz-CotorroServicios Médicos de la Real Federación Española de Tenis (RFET), Barcelona, Spain.
Lorenzo MasciInstitute of Sports Exercise and Health (ISEH), London, UK.
Nicola MaffulliDepartment of Musculoskeletal Disorders, University of Salerno School of Medicine, Surgery and Dentistry, Salerno, Italy.
Lluís OrozcoInstitut de Teràpia Regenerativa Tissular (ITRT), Centro Médico Teknon Hospital, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In a previous study, the authors found that at 6 months after treatment with a 20 × 10 Purpose: To evaluate the outcomes of all patients (n = 20) at 12 months after BM-MSC treatment and observe if the Lp-PRP pretreated group experienced any type of advantage. Study Design: Cohort study; Level of evidence, 2. Methods: Both the BM-MSC and original Lp-PRP groups were assessed at 12 months after BM-MSC treatment with clinical examination, the visual analog scale (VAS) for pain during daily activities and sports activities, the Victorian Institute of Sport Assessment-Patella score for patellar tendinopathy, dynamometry, and magnetic resonance imaging (MRI). Differences between the 2 groups were compared with the Student Results: The 10 patients originally treated with BM-MSCs continued to show improvement in tendon structure in their MRI scans ( Conclusion: The 12-month follow-up outcomes after both groups of patients (n = 20) received BM-MSC treatment indicated that biological treatment was safe, there were no adverse effects, and the participants showed a highly statistically significant clinical improvement (

Indexed as

jumper’s kneemesenchymal stem cellspatellar tendinopathyregenerative medicinesports injury

Identifiers

PMID37711505
PMCPMC10498712

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.