Evidence map›Paper›PMID 37711385›Full record

ArticleFrontiers in molecular biosciences2023

The differing effects of a dual acting regulator on SIRT1.

Yujin Hur, Johnson Huynh, Emily Leong, Reena Dosanjh, Annemarie F Charvat, My H Vu, Zain Alam, Yue Tong Lee, Christiane C Cabreros, Emma C Carroll and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yujin HurDepartment of Chemistry, San José State University, San José, CA, United States.
Johnson HuynhDepartment of Chemistry, San José State University, San José, CA, United States.
Emily LeongDepartment of Chemistry, San José State University, San José, CA, United States.
Reena DosanjhDepartment of Chemistry, San José State University, San José, CA, United States.
Annemarie F CharvatDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, United States.
My H VuDepartment of Chemistry, San José State University, San José, CA, United States.
Zain AlamDepartment of Chemistry, San José State University, San José, CA, United States.
Yue Tong LeeDepartment of Chemistry, San José State University, San José, CA, United States.
Christiane C CabrerosDepartment of Chemistry, San José State University, San José, CA, United States.
Emma C CarrollDepartment of Chemistry, San José State University, San José, CA, United States.
Greg L HuraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.
Ningkun WangDepartment of Chemistry, San José State University, San José, CA, United States.
San Jose State University · USLawrence Berkeley National Laboratory · USUniversity of California, San Francisco · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
Elucidating the Mechanism for Allosteric Regulation of SIRT1 through the N-Terminal RegionR16GM149377 · NIGMS · SAN JOSE STATE UNIVERSITY · PI Ningkun Wang · 2023 to 2026
$682k
Intramolecular Allosteric Regulation of SIRT1 Deacetylase Activity by the N-terminal DomainSC2GM132000 · NIGMS · SAN JOSE STATE UNIVERSITY · PI WANG, NINGKUN · 2019 to 2021
$415k
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R16 GM149377NIGMS NIH HHS SC2 GM132000NIH HHS S10 OD018483
6 · The paper itself

Abstract

SIRT1 is an NAD

Indexed as

allosteric regulationconformational changedeacetylaseenzyme kineticsSIRT1

Identifiers

PMID37711385
PMCPMC10499324
OpenAlexW4386331165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.